RESUMO
55 B.T. patients were treated with WHO Paucibacillary MDT (1982). The patients suffered from reversal reaction neither at the time of initiation of MDT nor prior to that. During the 6 months period of MDT, one patient developed reversal reaction of a skin patch, and another patient developed neuritis of a peripheral nerve trunk.
Assuntos
Dapsona/uso terapêutico , Hipersensibilidade Tardia/prevenção & controle , Hanseníase Dimorfa/tratamento farmacológico , Rifampina/uso terapêutico , Esquema de Medicação , Quimioterapia Combinada , Feminino , Humanos , Imunidade Celular/efeitos dos fármacos , Hanseníase Dimorfa/imunologia , MasculinoRESUMO
68 patients were included in a prospective study of the treatment of borderline leprosy. 34 were treated with dapsone 5 mg daily, and 34 with 50 mg daily. Reversal reactions developed in 11 of those on 5 mg daily and in 3 of those on 50 mg daily. The statistically significant difference between the two treatment groups indicates that, contrary to previous teaching, dapsone given in higher dosage does not predispose patients to reversal reactions and indeed may prevent them.