Assuntos
Neoplasias Otorrinolaringológicas/epidemiologia , Medicina Tropical/organização & administração , Medicina Tropical/tendências , Claritromicina/uso terapêutico , Resistência Microbiana a Medicamentos , Guiné/epidemiologia , Infecções por Helicobacter/tratamento farmacológico , Infecções por Helicobacter/epidemiologia , Doença pelo Vírus Ebola/epidemiologia , Doença pelo Vírus Ebola/prevenção & controle , Histoplasmose/epidemiologia , Hospitalização/estatística & dados numéricos , Humanos , Influenza Humana/epidemiologia , Influenza Humana/terapia , Hanseníase/epidemiologia , Neoplasias Otorrinolaringológicas/diagnóstico , Reunião/epidemiologia , Índice de Gravidade de DoençaRESUMO
Organized by Euroscicon, this meeting focused on the complex and fast-paced research field of T-cell subset phenotype and function. During the past 20 years, this field has moved on from the simple Th1-Th2 paradigm to the discovery of a range of T-cell subsets, including Tregs and Th17 cells. The meeting brought together a variety of researchers currently exploring this field, to give insight into what we know, what we need to know and the potential implications of this research in the medical setting.
Assuntos
Subpopulações de Linfócitos T/imunologia , Animais , Animais Selvagens/imunologia , Modelos Animais de Doenças , Filariose/imunologia , Filarioidea/imunologia , Marcação de Genes/métodos , Infecções por Helicobacter/imunologia , Helicobacter hepaticus/imunologia , Humanos , Doenças Inflamatórias Intestinais/imunologia , Hanseníase/imunologia , Malária/imunologia , Muridae/imunologia , Subpopulações de Linfócitos T/citologia , Células Th2/citologia , Células Th2/imunologiaRESUMO
We studied the prevalence of Helicobacter pylori in patients with leprosy and the effects of co-infection on the immune response to Helicobacter antigens in the polar groups of leprosy (lepromatous and tuberculoid). We showed that there is no difference in the prevalence of H. pylori in patients with leprosy as compared to a non-leprosy population. We also demonstrated that the immune response to low molecular weight H. pylori antigens (35, 26 and 19 kDa) differs in patients with lepromatous as compared to those with tuberculoid leprosy. In lepromatous leprosy, we show that there is a higher prevalence of the 35 and 26 kDa antigens, but a lower prevalence of the 19 kDa antigen. These immunological results are consistent with previous histopathological studies illustrating a more severe gastrointestinal inflammation in lepromatous patients; importantly, a response to the 35 kDa antigen is recognized as a marker for the development of ulcerative disease.
Assuntos
Antígenos de Bactérias/imunologia , Gastrite/microbiologia , Infecções por Helicobacter/imunologia , Helicobacter pylori/imunologia , Imunomodulação/imunologia , Hanseníase Virchowiana/imunologia , Hanseníase Tuberculoide/imunologia , Adulto , Idoso , Anticorpos Antibacterianos/análise , Anticorpos Antibacterianos/imunologia , Western Blotting , Estudos de Casos e Controles , Ensaio de Imunoadsorção Enzimática , Feminino , Gastrite/complicações , Gastrite/imunologia , Infecções por Helicobacter/complicações , Infecções por Helicobacter/microbiologia , Humanos , Hanseníase Virchowiana/complicações , Hanseníase Virchowiana/microbiologia , Hanseníase Tuberculoide/complicações , Hanseníase Tuberculoide/microbiologia , Masculino , Pessoa de Meia-Idade , EspanhaRESUMO
We studied the prevalence of Helicobacter pylori in patients with leprosy and the effects of co-infection on the immune response to Helicobacter antigens in the polar groups of leprosy (lepromatous and tuberculoid). We showed that there is no difference in the prevalence of H. pylori in patients with leprosy as compared to a non-leprosy population. We also demonstrated that the immune response to low molecular weight H. pylori antigens (35, 26 and 19 kDa) differs in patients with lepromatous as compared to those with tuberculoid leprosy. In lepromatous leprosy, we show that there is a higher prevalence of the 35 and 26 kDa antigens, but a lower prevalence of the 19 kDa antigen. These immunological results are consistent with previous histopathological studies illustrating a more severe gastrointestinal inflammation in lepromatous patients; importantly, a response to the 35 kDa antigen is recognized as a marker for the development of ulcerative disease.
Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Antígenos de Bactérias/imunologia , Gastrite , Infecções por Helicobacter/imunologia , Helicobacter pylori/imunologia , Imunomodulação/imunologia , Hanseníase Virchowiana/imunologia , Hanseníase Tuberculoide/imunologia , Anticorpos Antibacterianos , Anticorpos Antibacterianos/imunologia , Western Blotting , Estudos de Casos e Controles , Ensaio de Imunoadsorção Enzimática , Gastrite , Gastrite/imunologia , Infecções por Helicobacter , Infecções por Helicobacter , Hanseníase Virchowiana , Hanseníase Virchowiana , Hanseníase Tuberculoide , Hanseníase Tuberculoide , EspanhaAssuntos
Infecções por Helicobacter/epidemiologia , Pacientes Internados/estatística & dados numéricos , Hanseníase/microbiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Feminino , Helicobacter pylori , Hospitalização , Humanos , Hanseníase/epidemiologia , Masculino , Pessoa de Meia-IdadeRESUMO
Two antral biopsies each from 104 patients of leprosy and 100 controls were studied to find out the prevalence of H. pylori and associated histopathological changes. Sections were stained with hematoxylene and eosin, AB/PAS (Ph 2.5) and Loeffler's methylene blue stains. Infection by H. pylori, inflammation and atrophy were found to be significantly more in leprosy patients as compared to controls (p < 0.01, < 0.005 and < 0.02 respectively). On comparing the histopathological changes in various subgroups of leprosy, H. pylori, inflammation and activity showed a statistically decreasing trend from tuberculoid to lepromatous subgroups (p < 0.05, < 0.001, < 0.01 respectively). Atrophy showed a significant increasing trend from tuberculoid to lepromatous group (< 0.001), it is concluded that despite a low prevalence of H. pylori and associated gastritis in patients with lepromatous leprosy, gastric epithelial damage is more marked due to altered immune response.