Assuntos
Dermoscopia/métodos , Leiomioma/diagnóstico , Leiomiomatose/diagnóstico , Síndromes Neoplásicas Hereditárias/diagnóstico , Neoplasias Cutâneas/diagnóstico , Neoplasias Uterinas/diagnóstico , Adulto , Feminino , Humanos , Leiomioma/complicações , Leiomiomatose/complicações , Síndromes Neoplásicas Hereditárias/complicações , Neoplasias Cutâneas/complicações , Neoplasias Uterinas/complicaçõesRESUMO
Since the seminal work by Hans-Jörgen Hansen in 1952, it has been assumed that intervertebral disc (IVD) degeneration in chondrodystrophic (CD) dogs involves chondroid metaplasia of the nucleus pulposus, whereas in nonchondrodystrophic (NCD) dogs, fibrous metaplasia occurs. However, more recent studies suggest that IVD degeneration in NCD and CD dogs is more similar than originally thought. Therefore, the aim of this study was to compare the histopathology of IVD degeneration in CD and NCD dogs. IVDs with various grades of degeneration (Thompson grade I-III, n = 7 per grade) from both CD and NCD dogs were used (14 CD and 18 NCD dogs, 42 IVDs in total). Sections were scored according to a histological scoring scheme for canine IVD degeneration, including evaluation of the presence of fibrocyte-like cells in the nucleus pulposus. In CD dogs, the macroscopically non-degenerated nucleus pulposus contained mainly chondrocyte-like cells, whereas the non-degenerated nucleus pulposus of NCD dogs mainly contained notochordal cells. The histopathological changes in degenerated discs were similar in CD and NCD dogs and resembled chondroid metaplasia. Fibrocytes were not seen in the nucleus pulposus, indicating that fibrous degeneration of the IVD was not present in any of the evaluated grades of degeneration. In conclusion, intervertebral disc degeneration was characterized by chondroid metaplasia of the nucleus pulposus in both NCD and CD dogs. These results revoke the generally accepted concept that NCD and CD dogs suffer from a different type of IVD degeneration, in veterinary literature often referred to as chondroid or fibroid degeneration, and we suggest that chondroid metaplasia should be used to describe the tissue changes in the IVD in both breed types.
Assuntos
Doenças do Cão/patologia , Degeneração do Disco Intervertebral/veterinária , Leiomioma/metabolismo , Animais , Doenças das Cartilagens/patologia , Doenças das Cartilagens/veterinária , Cães , Feminino , Disco Intervertebral/patologia , Degeneração do Disco Intervertebral/patologia , Artropatias/patologia , Artropatias/veterinária , Leiomioma/patologia , MasculinoRESUMO
BACKGROUND: "Tender cutaneous nodules of the legs" is a common manifestation in dermatology. Histopathological investigation is usually required for this condition, because clinical data are frequently insufficient to make a definite diagnosis. OBJECTIVE: To identify and analyze the causes of patients presenting with tender leg nodules and to reveal clinical clues that could help to differentiate causes. MATERIALS AND METHODS: The medical records and histopathological slides of patients presenting with tender cutaneous nodules of the legs between January 2005 and December 2007 were retrospectively reviewed. RESULTS: Of the total of 154 patients, 122 (79.2%) were female. Definite diagnoses were categorized into four groups: inflammation (84.4%); infection (5.8%); tumor (6.5%); and nonspecific (3.2%). The most common cause in the inflammation group was erythema nodosum. The infections found were Acremonium spp., Penicillium sp., Mycobacterium abscessus, Mycobacterium fortuitum and Mycobacterium leprae. The tumors included leiomyoma, leukemia cutis, and lymphomas. Clinical data that correlated with and could be used as clues for the inflammation group were female sex (P = 0.03, OR 6.43) and lower leg involvement (P = 0.03, OR 7.14). LIMITATIONS: The retrospective manner of this study is a limitation. CONCLUSION: Various inflammatory conditions, infections, and tumors can present as tender cutaneous nodules of the legs. Female sex and lower leg involvement were clinical data that could be used as clues for the diagnoses in the inflammation group. However, histopathological investigation is still crucial to determine a definite diagnosis in patients presenting with tender cutaneous nodules of the legs.
Assuntos
Perna (Membro)/patologia , Dermatopatias/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Dermatomicoses/diagnóstico , Eritema Nodoso/diagnóstico , Feminino , Humanos , Leiomioma/diagnóstico , Leucemia/diagnóstico , Linfoma/diagnóstico , Masculino , Pessoa de Meia-Idade , Paniculite/diagnóstico , Estudos Retrospectivos , Dermatopatias Bacterianas/diagnóstico , Dermatopatias Bacterianas/microbiologia , Neoplasias Cutâneas/diagnóstico , Vasculite Leucocitoclástica Cutânea/diagnóstico , Adulto JovemRESUMO
Apresentamos uma atualizaçäo sobre as dermatoses que ocorrem no pavilhäo auricular. Propomos uma classificaçäo em sete grupos e realizamos uma sucinta descriçäo clínica de cada uma das 84 entidades catalogadas, de forma didática, com a finalidade de auxiliar o médico, sobretudo o clínico geral, o dermatologista e o otorrinolaringologista, no diagnóstico de tais patologias.
Assuntos
Humanos , Orelha/patologia , Dermatoses Faciais/patologia , Acne Vulgar/patologia , Actinomicose/patologia , Amiloidose/patologia , Aspergilose/patologia , Candidíase Cutânea/patologia , Carcinoma , Carcinoma de Células Escamosas/patologia , Carcinoma Basocelular/patologia , Celulite (Flegmão)/patologia , Cromoblastomicose/patologia , Cisto Epidérmico/patologia , Dermatite Atópica/patologia , Erisipela/patologia , Dermatoses Faciais/classificação , Furunculose/patologia , Hanseníase Virchowiana/patologia , Herpes Zoster/patologia , Hipertricose/patologia , Queloide/patologia , Leiomioma/patologia , Sarampo/patologia , Mieloma Múltiplo/patologia , Molusco Contagioso/patologia , Mucinoses/patologia , Nevo/patologia , Ocronose/patologia , Otite Externa/patologia , Paracoccidioidomicose/patologia , Pelagra/patologia , Pitiríase Rósea/patologia , Pitiríase/patologia , Rinosporidiose/patologia , Rubéola (Sarampo Alemão)/patologia , Esporotricose/patologia , Tuberculose Cutânea/patologia , Verrugas/patologiaAssuntos
Acne Vulgar/patologia , Actinomicose/patologia , Amiloidose/patologia , Aspergilose/patologia , Candidíase Cutânea/patologia , Carcinoma , Carcinoma de Células Escamosas/patologia , Celulite/patologia , Cisto Epidérmico/patologia , Cromoblastomicose/patologia , Dermatite Atópica/patologia , Erisipela/patologia , Esporotricose/patologia , Furunculose/patologia , Hanseníase Virchowiana/patologia , Herpes Zoster/patologia , Hipertricose/patologia , Leiomioma/patologia , Mieloma Múltiplo/patologia , Molusco Contagioso/patologia , Mucinoses/patologia , Nevo/patologia , Ocronose/patologia , Otite Externa/patologia , Paracoccidioidomicose/patologia , Pelagra/patologia , Pitiríase Rósea/patologia , Pitiríase/patologia , Queloide/patologia , Rinosporidiose/patologia , Sarampo/patologia , Tuberculose Cutânea/patologia , Verrugas/patologiaRESUMO
A 54-year-old immunosuppressed cardiac transplant recipient with a six-month history of progressive swelling of the hand, with nodules and linear lymph node chain enlargement, diagnosed as a sporotrichoid Mycobacterium avium-intracellulare pseudotumor is described. The microscopic features closely resembled the previously described histoid variety of lepromatous leprosy. Routine hematoxylin and eosin staining suggested a spindle cell neoplasm rather than an infectious or inflammatory process. An infectious etiology was pursued on the basis of the clinical setting.