Rabies, tetanus, leprosy, and malaria.

The developing world is still endemic to rabies, tetanus, leprosy, and malaria. Globally more than 55000 people die of rabies each year, about 95% in Asia and Africa. Annually, more than 10 million people, mostly in Asia, receive postexposure vaccination against the disease. World Health Organization estimated tetanus-related deaths at 163000 in 2004 worldwide. Globally, the annual detection of new cases of leprosy continues to decline and the global case detection declined by 3.54% during 2008 compared to 2007. Malaria is endemic in most countries, except the US, Canada, Europe, and Russia. Malaria accounts for 1.5-2.7 million deaths annually. Much of the disease burden related to these four infections is preventable.

The role of infectious agents in the aetiology and pathogenesis of childhood nephrotic syndrome in Africa.

Childhood nephrotic syndrome is common in Africa where infectious agents are prevalent. This paper reviews the possible aetiological role of infectious agents in childhood nephrotic syndrome in Africa. There is a strong association, possibly causal, between childhood nephrotic syndrome on the one hand and Plasmodium malariae, Schistosoma mansoni and hepatitis B antigens on the other. Beta-haemolytic streptococci are less strongly associated with nephrotic syndrome, and a few other organisms are suspect. The many ubiquitous infectious agents and the prevalence of multiple infections make it difficult to define the role of any single infectious agent or to determine the interaction between the various agents. Control or eradication of infectious diseases should lower the incidence of childhood nephrotic syndrome in Africa.

Splenomegaly in Zambia.

In this paper is reported the results of spleen surveys carried out as the opportunity arose in various groups in Zambia during the period January 1965 to October 1968. The lowest spleen rates were found in urban workers and in long stay adults in leprosy and psychiatric hospitals. The highest rates were in rural school children and children in a rural hospital. Intermediate between these groups were adults in an urban and in a rural general hospital.

Geographical distribution of amyloidosis in Papua New Guinea.

During an 11 year period 73 cases of amyloidosis were diagnosed at Port Moresby General Hospital as a result of histological examination of autopsy or biopsy material. No case of amyloidosis came from either the Highlands or North Coast regions although these two areas together accounted for 16% of the medical admissions at the hospital and made up a similar percentage of Port Moresby's Papua New Guinean population. Within the sub-district in which Port Moresby is situated there was a much higher incidence of amyloidosis in the inland, more sparsely populated, census divisions of the sub-district. Aetiological factors which may be related to the common occurrence of amyloidosis in Papua New Guinea are discussed in light of the observed geographical distribution of cases.