RESUMO
Hypopigmented mycosis fungoides (HMF) is a rare variant of patch stage MF, which is often misdiagnosed. A 35-year-old male presented with non-pruritic white patches on his chest that had been present for 10 years. The patient had previously been treated for leprosy without any improvement. Physical examination showed well-defined multiple hypopigmented patches and macules on the chest, posterior trunk, and gluteus, with some lesions exhibiting anhidrosis and central erythema. The result of sensibility examination was unclear. Slit-skin-smear examination for acid-fast bacilli and anti-phenolic-glycolipid-1 examination were negative. Histopathological examination showed Pautrier microabscesses. The patient was diagnosed with HMF and was treated with 16 mg methylprednisolone b.i.d., topical application of desoximetasone, and 1% methoxsalen lotion followed by sun exposure. A significant improvement was observed during the following 6 months. This case shows that HMF needs to be considered in patients presenting with chronic unexplained hypopigmented patches to avoid unnecessary treatment and progression to more advanced stages.
Assuntos
Hipopigmentação , Hanseníase , Micose Fungoide , Neoplasias Cutâneas , Corticosteroides , Adulto , Humanos , Hipopigmentação/diagnóstico , Hipopigmentação/tratamento farmacológico , Masculino , Micose Fungoide/diagnóstico , Micose Fungoide/tratamento farmacológicoAssuntos
Antimetabólitos Antineoplásicos/administração & dosagem , Metotrexato/administração & dosagem , Micose Fungoide/tratamento farmacológico , Micose Fungoide/radioterapia , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/radioterapia , Terapia Combinada/métodos , Relação Dose-Resposta a Droga , Feminino , Humanos , Pessoa de Meia-Idade , Micose Fungoide/diagnóstico , Neoplasias Cutâneas/diagnóstico , Resultado do Tratamento , Raios XAssuntos
Leucemia Linfocítica Crônica de Células B/diagnóstico , Metotrexato/administração & dosagem , Micose Fungoide/diagnóstico , Psoríase/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso , Fármacos Dermatológicos/administração & dosagem , Esquema de Medicação , Humanos , Leucemia Linfocítica Crônica de Células B/complicações , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Masculino , Micose Fungoide/complicações , Micose Fungoide/tratamento farmacológico , Psoríase/complicações , Psoríase/tratamento farmacológico , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/tratamento farmacológicoRESUMO
BACKGROUND: Granulomatous mycosis fungoides is an unusual histopathological variant of cutaneous T-cell lymphoma without clinical distinction from classic mycosis fungoides. Symptoms associated with peripheral nerve involvement have rarely been reported in the literature. CASE REPORT: The authors described a case of granulomatous MF stage IIB with large cell transformation who initially presented with leprosy-like condition and chronic left peroneal neuropathy The patient received six courses ofgemcitabine with greater than 90% improvement of skin lesions. The rest of the lesions were successfully treated with local electron beam radiation. CONCLUSION: Granulomatous MF with neuropathy can be clinically misdiagnosed if there is no histopathological and immunohistochemical finding to support the diagnosis of lymphoma.
Assuntos
Granuloma/diagnóstico , Micose Fungoide/diagnóstico , Neoplasias Cutâneas/diagnóstico , Antimetabólitos Antineoplásicos/uso terapêutico , Transformação Celular Neoplásica/patologia , Desoxicitidina/análogos & derivados , Desoxicitidina/uso terapêutico , Erros de Diagnóstico , Progressão da Doença , Granuloma/complicações , Granuloma/patologia , Humanos , Hanseníase/diagnóstico , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Debilidade Muscular/etiologia , Debilidade Muscular/patologia , Micose Fungoide/complicações , Micose Fungoide/tratamento farmacológico , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/patologia , Resultado do Tratamento , GencitabinaAssuntos
Metotrexato/administração & dosagem , Micose Fungoide/diagnóstico , Prednisolona/administração & dosagem , Neoplasias Cutâneas/diagnóstico , Idoso de 80 Anos ou mais , Quimioterapia Combinada , Humanos , Masculino , Micose Fungoide/tratamento farmacológico , Neoplasias/diagnóstico , Neoplasias/tratamento farmacológico , Neoplasias Cutâneas/tratamento farmacológicoRESUMO
A patient with mycosis fungoides that had progressed to tumor stage responded to chemotherapy and electron beam treatment, but 6 years later a peripheral neuropathy, extensive plaques, erythroderma, and enlarged pinnae containing acid-fast organisms developed while he was being treated with photopheresis. The skin lesions cleared with administration of rifampin and dapsone, but a reversal reaction biopsy specimen showed features of both mycosis fungoides and leprosy. This case raises the question of whether there may be an association between mycosis fungoides and leprosy.