RESUMO
Localized or pretibial myxedema is one of the signs of Graves disease (along with goiter, exophthalmus, thyroid acropathy, and high circulating levels of long-acting thyroid-stimulating hormone) and usually tends to occur at a later stage of the disease or even after the patient becomes euthyroid post treatment. Very rarely has it been reported in euthyroid patients. We report a euthyroid man presenting with localized myxedema on the extensor surface of his forearm with clinical and histopathological features consistent with pretibial myxedema. He responded partially to topical clobetasol propionate cream and tacrolimus ointment 0.1 percent for about 7 months. To the best of our knowledge, this is the first case of preradial myxedema in a euthyroid patient in the English international dermatological literature.
Assuntos
Erros de Diagnóstico , Mucinas/análise , Mixedema/diagnóstico , Hormônios Tireóideos/sangue , Idoso , Anti-Inflamatórios/uso terapêutico , Biópsia , Clobetasol/uso terapêutico , Antebraço , Humanos , Hipertireoidismo/diagnóstico , Imunossupressores/uso terapêutico , Hanseníase/diagnóstico , Masculino , Mixedema/sangue , Mixedema/tratamento farmacológico , Mixedema/etiologia , Mixedema/metabolismo , Pele/patologia , Tacrolimo/uso terapêuticoAssuntos
Mucinas , Nevo Sebáceo de Jadassohn/diagnóstico , Nevo Sebáceo de Jadassohn/patologia , Fatores Etários , Idoso , Feminino , Humanos , Ceratolíticos/administração & dosagem , Mucinas/análise , Nevo/diagnóstico , Nevo/tratamento farmacológico , Nevo/patologia , Nevo Sebáceo de Jadassohn/tratamento farmacológicoRESUMO
Three specimens of simple nasal polyps which were examined in a routine histopathology laboratory contained tubereuloid granulomas. One of these patients was found to have systemic sarcoidosis. The other two continue to be asymptomatic and in one of these rupture of cystic nasal mucous glands with the liberation of epithelial mucin into the stroma appears to have excited the granulomatous reaction. The causation, investigation and significance of granulomas at this site are discussed.