Assuntos
Fracionamento da Dose de Radiação , Linfoma de Zona Marginal Tipo Células B/patologia , Complicações Neoplásicas na Gravidez/patologia , Neoplasias Cutâneas/patologia , Neoplasias Vulvares/patologia , Aborto Terapêutico/métodos , Adulto , Biópsia por Agulha , Feminino , Seguimentos , Idade Gestacional , Humanos , Imuno-Histoquímica , Linfoma de Zona Marginal Tipo Células B/radioterapia , Linfoma de Zona Marginal Tipo Células B/cirurgia , Gravidez , Complicações Neoplásicas na Gravidez/radioterapia , Complicações Neoplásicas na Gravidez/cirurgia , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/cirurgia , Resultado do Tratamento , Neoplasias Vulvares/diagnóstico , Neoplasias Vulvares/radioterapiaRESUMO
Extramammary Paget's disease and Bowen's disease are histologically similar and immunohistochemistry is often required to make the diagnosis. We present a case of vulval Paget's disease with Bowen's disease in an elderly female. Strong positivity for cytokeratin 7, anti CAM 5.2, carcinoembryonic antigen (CEA) and periodic acid-Schiff (PAS) stain in clitoral, left labial and interface regions of the vulvectomy specimen confirmed the diagnosis of Paget's disease (PD) while positive staining for p63 in the right labial and interface regions helped in establishing the diagnosis of concurrent Bowen's disease (BD).
Assuntos
Doença de Bowen/patologia , Neoplasias Primárias Múltiplas/patologia , Doença de Paget Extramamária/patologia , Neoplasias Cutâneas/patologia , Neoplasias Vulvares/patologia , Biomarcadores/análise , Doença de Bowen/química , Doença de Bowen/cirurgia , Antígeno Carcinoembrionário/análise , Feminino , Humanos , Queratina-7/análise , Queratinas/análise , Proteínas de Membrana/análise , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/química , Neoplasias Primárias Múltiplas/cirurgia , Doença de Paget Extramamária/química , Doença de Paget Extramamária/cirurgia , Neoplasias Cutâneas/química , Neoplasias Cutâneas/cirurgia , Neoplasias Vulvares/química , Neoplasias Vulvares/cirurgiaRESUMO
Aggressive angiomyxoma is a rare, slow-growing mesenchymal neoplasm with a tendency to recur. It mainly involves the pelvis, vulva, perineum, vagina, and urinary bladder in adult women of reproductive age group. We describe a 26-year-old female with large swellings of both labia majora which was histologically diagnosed as aggressive angiomyxoma. She also had systemic lupus erythematosus. The swelling was surgically removed and she had no recurrence at 1-year follow-up. Although it is a rare tumor, it must be considered as a differential diagnosis for any mass in the perineum or soft tissue of the pelvis. Long-term follow-up is necessary for early diagnosis of local recurrence.
Assuntos
Lúpus Eritematoso Sistêmico/complicações , Mixoma/complicações , Mixoma/patologia , Vulva/patologia , Neoplasias Vulvares/complicações , Neoplasias Vulvares/patologia , Adulto , Exantema/complicações , Exantema/patologia , Feminino , Humanos , Mixoma/cirurgia , Índice de Gravidade de Doença , Neoplasias Vulvares/cirurgiaRESUMO
A 55-year-old lady presented with a large skin colored growth on her vulva since the age of 15 years, which gradually increased to the present state, with the development of a new lesion on her left thigh. There were no systemic symptoms. Biopsy followed by immunohistochemistry showed features consistent with a granular cell tumor.
Assuntos
Tumor de Células Granulares/diagnóstico , Neoplasias Vulvares/diagnóstico , Feminino , Tumor de Células Granulares/patologia , Humanos , Pessoa de Meia-Idade , Neoplasias Vulvares/patologiaRESUMO
Vulvar vestibular papillomatosis is considered an anatomical variant of the vulva. Recognition of this condition enables one to distinguish it from warts and therefore avoid unnecessary therapy. A 29-year-old lady presented to this clinic with a history of 'small growths' in her vulva since two years. Examination identified skin colored translucent papules; some of them appeared digitate and were seen on the vestibule and inner aspect of both labia minora. They were soft to feel and non-tender. Few lesions looked like elongated pearly penile papules. A provisional diagnosis of vestibular papillomatosis was made and a biopsy was done. It showed finger-like protrusions of loosely arranged subdermal tissue with blood vessels and which were covered by normal mucosal epithelium. No koilocytes were seen and the diagnosis of vestibular papillomatosis was confirmed. We believe that this is the first case report of vulvar vestibular papillomatosis in Indian dermatologic literature.