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1.
PLoS Negl Trop Dis ; 16(4): e0010393, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-35486667

RESUMO

Leprosy is still a prevalent disease in Brazil, representing 93% of all occurrences in the Americas. Leprosy neuropathy is one of the most worrying manifestations of the disease. Acute neuropathy usually occurs during reaction episodes and is called neuritis. Twenty-two leprosy patients were included in this study. These patients had neural pain associated with ulnar sensory neuropathy, with or without adjunct motor involvement. The neurological picture began within thirty days of the clinical evaluation. The patients underwent a nerve conduction study and the demyelinating findings confirmed the diagnosis of neuritis. Ultrasonographic study (US) of the ulnar nerve was performed in all patients by a radiologist who was blinded to the clinical or neurophysiological results. Morphological characteristics of the ulnar nerve were analyzed, such as echogenicity, fascicular pattern, transverse cross-sectional area (CSA), aspect of the epineurium, as well as their anatomical relationships. The volume of selected muscles referring to the ulnar nerve, as well as their echogenicity, was also examined. Based on this analysis, patients with increased ulnar nerve CSA associated with loss of fascicular pattern, epineurium hyperechogenicity and presence of power Doppler flow were classified as neuritis. Therefore, patients initially classified by the clinical-electrophysiological criteria were reclassified by the imaging criteria pre-established in this study as with and without neuritis. Loss of fascicular pattern and flow detection on power Doppler showed to be significant morphological features in the detection of neuritis. In 38.5% of patients without clinical or neurophysiological findings of neuritis, US identified power Doppler flow and loss of fascicular pattern. The US is a method of high resolution and portability, and its low cost means that it could be used as an auxiliary tool in the diagnosis of neuritis and its treatment, especially in basic health units.


Assuntos
Hanseníase , Neuralgia , Neurite (Inflamação) , Neuropatias Ulnares , Humanos , Hanseníase/complicações , Hanseníase/diagnóstico por imagem , Condução Nervosa , Neurite (Inflamação)/diagnóstico por imagem , Neurite (Inflamação)/etiologia , Nervo Ulnar/diagnóstico por imagem , Neuropatias Ulnares/diagnóstico por imagem , Ultrassonografia
2.
Clin Nucl Med ; 43(2): 132-133, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29261639

RESUMO

Uses of FDG PET/CT have been previously documented in multiple series in peripheral nerve pathologies, including neurolymphomatosis, peripheral nerve sheath tumor, and plexopathies. We present the case of a 24-year-old man with leprosy neuritis who underwent FDG PET/CT. We suggest that FDG PET/CT can be used as an adjunct tool to monitor neuritis in leprosy patients.


Assuntos
Fluordesoxiglucose F18 , Hanseníase/complicações , Neurite (Inflamação)/complicações , Neurite (Inflamação)/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Humanos , Masculino , Adulto Jovem
3.
PLoS Negl Trop Dis ; 10(11): e0005111, 2016 11.
Artigo em Inglês | MEDLINE | ID: mdl-27851766

RESUMO

BACKGROUND: Previous studies have shown that leprosy multi-drug therapy (MDT) does not stop the progression of nerve function impairment. There are no prospective studies investigating the evolution of nerve anatomic abnormalities after treatment. We examined leprosy patients aiming to investigate the evolution of nerve ultrasonography (US) abnormalities and the risk factors for poor outcomes after MDT. METHODOLOGY/PRINCIPAL FINDINGS: We performed bilateral US of the ulnar (U), median (M) and common fibular (CF) nerves in 9 paucibacillary (PB) and 64 multibacillary (MB) patients before and after MDT. Forty-two patients had leprosy reactions (type 1, type 2, acute neuritis) during the study. We analyzed nerve maximum cross-sectional areas (CSA), echogenicity and Doppler signal. Poor outcomes included a post-treatment CSA above normal limits with a reduction of less than 30% (U, M) or 40% (CF) from the baseline, echogenicity abnormalities or intraneural Doppler in the post-treatment study. We found that PB and patients without reactions showed significant increases in CSA at CF, whereas MB and patients with reactions had CSA reduction in some nerves after treatment (p<0.05). Despite this reduction, we observed a greater frequency of poor CSA outcomes in the MB compared to the PB (77.8% and 40.6%; p>0.05) and in the patients with reactions compared to those without (66.7% and 38.7%; p<0.05). There was significantly higher odds ratio (7.75; 95%CI: 1.56-38.45) for poor CSA outcomes only for M nerve in patients with reactions. Poor echogenicity outcomes were more frequent in MB (59.4%) compared to PB (22.2%) (p<0.05). There was significant association between poor Doppler outcomes and neuritis. Gender, disease duration, and leprosy classification were not significant risk factors for poor outcomes in CSA, echogenicity or Doppler. CONCLUSIONS/SIGNIFICANCE: US nerve abnormalities can worsen after treatment despite the leprosy classification or the presence of reactions.


Assuntos
Hansenostáticos/efeitos adversos , Hanseníase/complicações , Neurite (Inflamação)/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Hanseníase/tratamento farmacológico , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Sistema Nervoso/diagnóstico por imagem , Sistema Nervoso/efeitos dos fármacos , Neurite (Inflamação)/etiologia , Estudos Prospectivos , Ultrassonografia , Adulto Jovem
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