Assuntos
Hanseníase Dimorfa/complicações , Hanseníase Virchowiana/complicações , Orquite/complicações , Seminoma/etiologia , Neoplasias Testiculares/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Mycobacterium leprae/isolamento & purificação , Orquite/etiologia , Seminoma/patologia , Neoplasias Testiculares/patologia , Testículo/microbiologia , Testículo/patologia , Tuberculose Pulmonar/complicaçõesRESUMO
Twenty five patients of lepromatous leprosy were studied clinically and histopathologically for testicular involvement. Testicular pain or swelling was the commonest complaint (68%) followed by sterility (28%) and impotence (4%). Reduced testicular size associated with soft feel was observed in 76% patients. Gynaecomastia was present in 36% and altered sexual hair pattern in 24%. Eleven out of sixteen (69%) patients had oligo/azoospermia. Out of the twenty testicular biopsies 15 (75%) had definite histological evidence of leprous pathology, irrespective of testicular size, semen picture and clinical signs and symptoms. One out of three epididymal biopsies showed minimal changes. Histopathological changes varied markedly, it was not possible to categorize these into vascular, interstitial and obliterative phases.
Assuntos
Hanseníase/patologia , Orquite/patologia , Testículo/patologia , Adolescente , Adulto , Idoso , Atrofia , Humanos , Hanseníase/complicações , Hanseníase/imunologia , Células Intersticiais do Testículo/patologia , Masculino , Pessoa de Meia-Idade , Orquite/etiologia , Orquite/imunologia , Túbulos Seminíferos/patologiaRESUMO
Twenty five patients of lepromatous leprosy were studied clinically and histopathologically for testicular involvement. Testicular pain or swelling was the commonest complaint (68%) followed by sterility (28%) and impotence (4%). Reduced testicular size associated with soft feel was observed in 76% patients. Gynaecomastia was present in 36% and altered sexual hair pattern in 24%. Eleven out of sixteen (69%) patients had oligo/azoospermia. Out of the twenty testicular biopsies 15 (75%) had definite histological evidence of leprous pathology, irrespective of testicular size, semen picture and clinical signs and symptoms. One out of three epididymal biopsies showed minimal changes. Histopathological changes varied markedly, it was not possible to categorize these into vascular, interstitial and obliterative phases.
Assuntos
Masculino , Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Adolescente , Atrofia , Células Intersticiais do Testículo/patologia , Hanseníase/complicações , Hanseníase/imunologia , Hanseníase/patologia , Orquite/etiologia , Orquite/imunologia , Orquite/patologia , Testículo/patologia , Túbulos Seminíferos/patologiaRESUMO
In a preliminary study, 11 male patients with lepromatous leprosy were evaluated with regard to endocrinopathy and hormonal status. Basal circulating hormone levels were estimated with a view to correlating the biochemical findings and clinical features. Thyroid hormones T3 and T4, Free Thyroxine Index (FTI), TSH, and cortisol were within normal limits, indicating that further study of these hormones would not be worthwhile. The finding of elevated levels of prolactin as well as the gonadotrophins LH and FSH, however, promises to yield more valuable information if studied in greater detail in a larger group of patients.