RESUMO
Scalp mucormycosis in children is extremely rare. We present a case of pediatric scalp mucormycosis caused by Rhizopus oryzae in a 9-year-old diabetic girl who was successfully diagnosed and treated with amphotericin B deoxycholate and wound debridement. At 3 months follow up, the patient was stable although she had lost her vision.
Assuntos
Dermatomicoses/diagnóstico , Diabetes Mellitus Tipo 1/diagnóstico , Pálpebras/patologia , Mucormicose/diagnóstico , Couro Cabeludo/patologia , Criança , Dermatomicoses/complicações , Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 1/terapia , Pálpebras/microbiologia , Feminino , Seguimentos , Humanos , Mucormicose/complicações , Mucormicose/terapia , Rhizopus/isolamento & purificação , Couro Cabeludo/microbiologia , Transtornos da Visão/diagnóstico , Transtornos da Visão/etiologiaRESUMO
Fungi in the class of zygomycetes usually produce serious infections in diabetics and immunocompromised hosts. Cutaneous zygomycosis is a less common form, with an unpredictable extent of anatomical involvement and clinical course. Here, we report two cases of primary cutaneous zygomycosis as postoperative complications in otherwise healthy females. Zygomycosis was suspected and specimens from the surgical debridement were examined by microbiological and histopathological studies for confirming the clinical diagnosis. Rapid diagnosis, liposomal amphotericin B, and proper debridement of affected tissue are necessary to avoid a fatal outcome.
Assuntos
Imunocompetência , Rhizopus , Infecção da Ferida Cirúrgica/imunologia , Infecção da Ferida Cirúrgica/microbiologia , Zigomicose/imunologia , Adulto , Cesárea , Dermatomicoses/imunologia , Dermatomicoses/microbiologia , Dermatomicoses/terapia , Feminino , Humanos , Laparotomia , Cistos Ovarianos/cirurgia , Gravidez , Infecção da Ferida Cirúrgica/terapia , Adulto JovemRESUMO
A series of (R)- and (S)-1-alkyn-3-ols, chiral building units for the synthesis of leukotrienes and pheromones, were prepared via enantioselective hydrolysis of their racemic esters. While the majority of biocatalysts employed (lipases, fermenting or freeze-dried microorganisms) failed in discriminating between enantiomers, lyophilized cells of baker's yeast (Saccharomyces cerevisiae Hansen) gave (S)-1-alkyn-3-ols and their corresponding (R)-esters with greater than 90% e.e.