RESUMO
Three diseases representative of specific health conditions affecting the Southeast Asian refugees living in middle Tennessee are leprosy (chronic bacterial infections), liver fluke infection (parasitic diseases), and hemoglobin E-beta-thalassemia (hematologic disorders). In this paper we discuss incidence, causative agent, mode of transmission, metabolic abnormalities, and management of these conditions.
Assuntos
Doenças Hematológicas/diagnóstico , Enteropatias Parasitárias/diagnóstico , Hanseníase/diagnóstico , Refugiados , Sudeste Asiático/etnologia , Dapsona/uso terapêutico , Quimioterapia Combinada , Feminino , Doenças Hematológicas/complicações , Hemoglobina E , Humanos , Recém-Nascido , Enteropatias Parasitárias/tratamento farmacológico , Laos/etnologia , Hanseníase/tratamento farmacológico , Masculino , Mebendazol/administração & dosagem , Pessoa de Meia-Idade , Niclosamida/administração & dosagem , Gravidez , Complicações Infecciosas na Gravidez/parasitologia , Esplenectomia , Tennessee , Talassemia/complicações , Talassemia/diagnóstico , Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/tratamento farmacológicoRESUMO
The beta-thalassemia trait was investigated among 165 Brazilians who were unmixed Italian descendants (80 Virchowian patients and 85 normal controls, composed of universitary students). The frequency of the beta-thalassemia trait was 6.25% among the Virchowian patients and 5.88% in the control group. In spite of the similar geographical distribution of both hanseniasis and the gene for beta-thalassemia in Asia, the present data does not support the hypothesis that hanseniasis might have contributed to maintain high prevalence of this allele by selection favouring beta-thalassemia trait.
Assuntos
Hanseníase/complicações , Talassemia/complicações , Feminino , Hemoglobina A2/análise , Humanos , Masculino , Talassemia/genéticaRESUMO
In 588 bloodsamples of negride natives from Moçambique, preferably Chuabo and Macua, haemoglobin analyses were performed. In 21 cases an increase of Hb A2 was found, indicating the presence of heterozygous beta-thalassaemia, in one case the changes in Hb-analysis were typical for beta-delta-thalassaemia, 18 samples could be shown to contain Hb S, typical for the heterozygous sickle cell trait. Futhermore in 7 cases Hb A2' was found. In two bloodsamples haemoglobin variants were observed, which according to their electrophoretical mobility were assumed to represent Hb D in one case, and Hb G in the other. In the Chuabo population the frequency of the thalassaemia gene was found to be more than twice as high as in the Macua population. In non-lepers Hb S was observed with a remarkable higher incidence than in lepers.