The armadillo as an animal model and reservoir host for Mycobacterium leprae
In. Virmond, Marcos da Cunha Lopes; Grzybowski, Andrzej. Clinics in Dermatology: Leprosy: 1. New York, Elsevier, 2015. p.108-115, ilus, mapa.
Não convencional
em Inglês
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1048502
Biblioteca responsável:
BR191.1
Localização: BR191.1; 9445/S / BR191.1; 9446/S
ABSTRACT
Apart from humans, armadillos are the only known natural hosts of Mycobacterium leprae. They are well developed as hosts for in vivo propagation of M leprae and are advancing as models for studying the pathogenesis of leprosy and translational research. Armadillos are immunologically intact. They exhibit the full Ridley-Jopling spectrum of histopathologic responses to M leprae and uniquely manifest extensive neurological involvement that closely recapitulates human leprosy. In addition, free-ranging armadillos in some regions are known to harbor a naturally occurring infection with M leprae, and zoonotic transmission between armadillos and humans has been implicated in a large number of new case presentations. We review the role of the armadillo as a model for leprosy and reservoir for human infection.
Tema:
Complicações
/
Epidemiologia
/
Geral
/
Transmissão
Bases de dados:
HANSEN
/
HANSENIASE
/
Sec. Est. Saúde SP
Assunto principal:
Tatus
/
Reservatórios de Doenças
/
Doenças do Sistema Nervoso Periférico
/
Hanseníase
/
Mycobacterium leprae
Idioma:
Inglês
Ano de publicação:
2015
Tipo de documento:
Não convencional
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