Effect of rifampin, clofazimine, and B1912 on the viability of Mycobacterium leprae in established mouse footpad infection
s.l; s.n; apr. 1976. 5 p. graf.
Non-conventional
em En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1240586
Biblioteca responsável:
BR191.1
Localização: [{"text": "BR191.1", "_a": "01652/s"}]
ABSTRACT
Continuous dietary administration of rifampin to mice with an established Mycobacterium leprae footpad infection reduced the bacillary solid ratio, with an estimated survival half-life of 5-6 days. In rifampin-treated immunosuppressed animals the survival half-life of solid bacilli, in the absence of host immunity, was 12-13 days. Clofazimine and B1912 produced a significant effect on solid ratio only after a lag period of apparently 100 days. The rate of action was considerably slower than that of rifampin. Intermittent (once monthly) administration of both drugs produced effects similar to those of continuous administration.
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Tema:
Complicacoes
/
Epidemiologia
/
Geral
/
Tratamento_medicamentoso
Bases de dados:
HANSEN
/
HANSENIASE
/
SES-SP
Assunto principal:
Rifampina
/
Fatores de Tempo
/
Terapia de Imunossupressão
/
Clofazimina
/
Hanseníase
/
Anticorpos Antibacterianos
/
Mycobacterium leprae
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Non-conventional