T Cells in immunodeficiencies as evaluated by an antihuman T-cell serum.
Birth Defects Orig Artic Ser
; 11(1): 22-7, 1975.
Article
em En
| MEDLINE
| ID: mdl-1096979
ABSTRACT
An antihuman T-cell has been prepared in rabbits by infecting lymphocytes from a patient with Bruton-type agammaglobulinemia and absorption with cultured B-lymphoblast cells. Cytotoxicity of the antiserum was assayed with peripheral blood lymphocytes in the presence of rabbit complement and its specificity for T vs B cells was verified. This anti-T-cell serum killed 66% (range 49-78) of normal blood lymphocytes. In patients with Bruton-type agammaglobulinemia the percentage of cells sensitive to the antiserum was above normal (77-89%), whereas it was decreased in some patients with lepromatous leprosy or under antilymphocyte globulin therapy.
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Tema:
Geral
/
Tratamento_medicamentoso
Bases de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Síndromes de Imunodeficiência
/
Soro Antilinfocitário
Idioma:
En
Revista:
Birth Defects Orig Artic Ser
Ano de publicação:
1975
Tipo de documento:
Article