Fusidic acid is highly active against extracellular and intracellular Mycobacterium leprae.
Antimicrob Agents Chemother
; 36(1): 92-4, 1992 Jan.
Article
em En
| MEDLINE
| ID: mdl-1590706
ABSTRACT
The activity of fusidic acid against Mycobacterium leprae was studied in axenic medium and in bacilli residing within mouse peritoneal macrophages. Activity was assessed by subsequent quantitation of bacillary radiorespirometric activity. Significant inhibition in both systems was observed at 0.156 micrograms/ml, and an approximately 50% reduction in activity occurred after exposure to 1.25 to 2.5 micrograms/ml. The excellent human pharmacokinetics and in vitro activity of fusidic acid against the leprosy bacillus warrant a clinical trial of this drug for leprosy.
Texto completo:
1
Tema:
Geral
Bases de dados:
MEDLINE
Assunto principal:
Ácido Fusídico
/
Mycobacterium leprae
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
1992
Tipo de documento:
Article