Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy.
Clin Infect Dis
; 42(2): 238-41, 2006 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-16355335
ABSTRACT
Molecular detection was compared with the mouse footpad inoculation test for detection of dapsone resistance in 38 strains of Mycobacterium leprae. Mutations of the folP1 gene (at codons 53 or 55) were found in 6 of 6 strains with high-level resistance, in 3 of 4 strains with intermediate-level resistance, and in 1 of 6 strains with low-level resistance, but not in 22 dapsone-susceptible strains. In cases of infection with strains of M. leprae carrying the folP1 mutation, therapy with dapsone may be replaced by therapy with a fluoroquinolone.
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Tema:
Complicacoes
/
Epidemiologia
/
Geral
/
Prevencao_controle
/
Tratamento_medicamentoso
Bases de dados:
MEDLINE
Assunto principal:
Recidiva
/
Mutação de Sentido Incorreto
/
Farmacorresistência Bacteriana
/
Dapsona
/
Di-Hidropteroato Sintase
/
Hanseníase
/
Mycobacterium leprae
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Clin Infect Dis
Ano de publicação:
2006
Tipo de documento:
Article