Your browser doesn't support javascript.
loading
TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional study.
J Infect Dis ; 204(8): 1256-63, 2011 Oct 15.
Article em En | MEDLINE | ID: mdl-21917899
Leprosy is an infectious disease caused by Mycobacterium leprae. Tumor necrosis factor (TNF) plays a key role in the host response. Some association studies have implicated the single nucleotide polymorphism TNF -308G>A in leprosy susceptibility, but these results are still controversial. We first conducted 4 association studies (2639 individuals) that showed a protective effect of the -308A allele (odds ratio [OR] = 0.77; P = .005). Next, results of a meta-analysis reinforced this association after inclusion of our new data (OR = 0.74; P = .04). Furthermore, a subgroup analysis including only Brazilian studies suggested that the association is specific to this population (OR = 0.63; P = .005). Finally, functional analyses using whole blood cultures showed that patients carrying the -308A allele produced higher TNF levels after lipopolysaccharide (LPS) (6 hours) and M. leprae (3 hours) stimulation. These results reinforce the association between TNF and leprosy and suggest the -308A allele as a marker of disease resistance, especially among Brazilians.
Assuntos

Texto completo: 1 Tema: Complicacoes / Epidemiologia / Geral / Transmissao Bases de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Hanseníase / Mycobacterium leprae Tipo de estudo: Observational_studies / Risk_factors_studies / Screening_studies / Systematic_reviews País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Infect Dis Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Tema: Complicacoes / Epidemiologia / Geral / Transmissao Bases de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Hanseníase / Mycobacterium leprae Tipo de estudo: Observational_studies / Risk_factors_studies / Screening_studies / Systematic_reviews País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Infect Dis Ano de publicação: 2011 Tipo de documento: Article