Structure-activity relationships of tetramethylpiperidine-substituted phenazines against Mycobacterium leprae in vitro.
Antimicrob Agents Chemother
; 33(11): 2004-5, 1989 Nov.
Article
em En
| MEDLINE
| ID: mdl-2692516
ABSTRACT
In a previous study of structure-activity relationships of selected phenazines against Mycobacterium leprae in vitro, compounds containing a 2,2,6,6-tetramethylpiperidine substitution at the imino nitrogen were most active. Therefore, the effect of substitution at the para positions of the phenyl and anilino groups in tetramethylpiperidine-substituted phenazines was assessed. As determined by radiorespirometry, activity in ascending order was observed in compounds substituted with hydrogens or fluorines, ethoxy groups, methyl groups, chlorines, and bromines and correlated with partition coefficients in octanol-water.
Texto completo:
1
Tema:
Geral
/
Transmissao
/
Tratamento_medicamentoso
Bases de dados:
MEDLINE
Assunto principal:
Clofazimina
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Antibacterianos
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Mycobacterium leprae
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
1989
Tipo de documento:
Article