Sebo-suppression by Combined Anti-androgen and Oestrogen in Female Acne Compared with Tetracycline.

ABSTRACT

Cyclic administration of a combination of cyproterone acetate and ethinyl oestradiol in 30 female acne patients led to a significant decrease of the cutaneous sebum excretion rate (SER) as assessed by the modified gravimetric technique. The mean percent reduction was 36.42 + 3. 07 at the end of 6 months, and, it remained reduced even after a treatment free period of 3 month. In comparison, tetracycline treated patients showed a slight rise in the SER that returned to near baseline values 3 months after cessation of the drug.