An immunohistochemical and morphological study of amyloidosis complicating leprosy in Malaysian patients.
Ann Acad Med Singap
; 17(4): 573-8, 1988 Oct.
Article
em En
| MEDLINE
| ID: mdl-3223746
ABSTRACT
Congo red screening of tissue blocks from 37 consecutive autopsies on leprosy patients revealed 7 cases of systemic amyloidosis, indicating a prevalence rate of 19%. 5 were males and 2 females. All were ethnic Chinese. Their ages ranged from 52 to 85 years with a mean of 69 years. Six had lepromatous leprosy while the remaining 1 had tuberculoid leprosy. In all 7 cases, the amyloid was AA in type, being permanganate-sensitive and immunoreactive with anti-human AA protein antiserum. Hepatic deposition was limited to blood vessels, a pattern typical of AA (secondary) amyloidosis. With regard to renal involvement, 4 showed a predominantly vascular pattern of infiltration while 3 exhibited the more ominous glomerular pattern. Three died of chronic renal failure and 2 of congestive cardiac failure attributable to renal and cardiac amyloidosis respectively. One patient succumbed to septicaemia and the remaining 1 to acute myocardial infarction. AA amyloidosis remains a serious and significant complication of leprosy among Malaysians.
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Tema:
Complicacoes
/
Epidemiologia
/
Geral
Bases de dados:
MEDLINE
Assunto principal:
Hanseníase Dimorfa
/
Hanseníase Virchowiana
/
Hanseníase Tuberculoide
/
Amiloidose
Tipo de estudo:
Risk_factors_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
Ann Acad Med Singap
Ano de publicação:
1988
Tipo de documento:
Article