Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization.
Rev Soc Bras Med Trop
; 56: e02652023, 2023.
Article
em En
| MEDLINE
| ID: mdl-37909507
ABSTRACT
While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1ß and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.
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Complicacoes
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Tratamento_medicamentoso
Bases de dados:
MEDLINE
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Citocinas
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Hanseníase
Idioma:
En
Revista:
Rev Soc Bras Med Trop
Ano de publicação:
2023
Tipo de documento:
Article