DMSO and colchicine therapy in amyloid disease.
Ann Rheum Dis
; 43(3): 421-3, 1984 Jun.
Article
em En
| MEDLINE
| ID: mdl-6742905
ABSTRACT
There is no specific therapy for primary amyloidosis, and acquired generalised amyloidosis can be treated only if the underlying disease is eliminated. In this study we have investigated the role of colchicine therapy in primary amyloidosis, and dimethylsulphoxide (DMSO) in leprosy associated secondary amyloidosis. No effect on creatinine clearance or 24 h proteinuria could be observed in the patients with primary amyloidosis. In the DMSO group renal function was considerably improved in 3 patients with moderate renal failure but not in those with severe renal impairment (creatinine clearance less than 10 ml/min). Serum SAA determinations were not particularly informative. These findings point to a beneficial effect of DMSO in human secondary amyloidosis when given at an early stage of renal involvement.
Texto completo:
1
Tema:
Complicacoes
/
Etiologia
/
Geral
/
Tratamento_medicamentoso
Bases de dados:
MEDLINE
Assunto principal:
Colchicina
/
Dimetil Sulfóxido
/
Amiloidose
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
Ann Rheum Dis
Ano de publicação:
1984
Tipo de documento:
Article