Primary dapsone resistance in Cebu, The Philippines; cause for concern.
Int J Lepr Other Mycobact Dis
; 64(3): 253-6, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8862258
ABSTRACT
At a time when primary dapsone resistance was prevalent in many leprosy endemic areas, Cebu in The Philippines reported only 3.6% in the period 1975-1978 and later 8.1% in the period 1979-1982. In our current study of patients in the period 1988-1992, the number increased dramatically to 52.7%. In addition, 7.9% of the isolates are highly resistant to dapsone, a level of resistance not seen in earlier studies. This finding could have severe ramifications to the World Health Organization's multidrug therapy (WHO-MDT) mode of treatment, where dapsone is one of the principal drugs. Moreover, the increase in primary dapsone resistance may be a contributing factor in the recent finding that there has been no decline in the number of new cases found in Cebu, even after the implementation of WHO-MDT in 1985. There is a need for new drugs that could be included in the multidrug treatment for multibacillary and paucibacillary leprosy.
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Tema:
Complicacoes
/
Epidemiologia
/
Geral
/
Tratamento_medicamentoso
Bases de dados:
MEDLINE
Assunto principal:
Resistência Microbiana a Medicamentos
/
Dapsona
/
Hansenostáticos
/
Mycobacterium leprae
Tipo de estudo:
Incidence_studies
/
Prevalence_studies
/
Risk_factors_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
Int J Lepr Other Mycobact Dis
Ano de publicação:
1996
Tipo de documento:
Article