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Structure and Function of the Mitochondrial Ribosome.

Greber, Basil J; Ban, Nenad.

Annu Rev Biochem ; 85: 103-32, 2016 Jun 02.

Article in English | MEDLINE | ID: mdl-27023846

ABSTRACT

Mitochondrial ribosomes (mitoribosomes) perform protein synthesis inside mitochondria, the organelles responsible for energy conversion and adenosine triphosphate production in eukaryotic cells. Throughout evolution, mitoribosomes have become functionally specialized for synthesizing mitochondrial membrane proteins, and this has been accompanied by large changes to their structure and composition. We review recent high-resolution structural data that have provided unprecedented insight into the structure and function of mitoribosomes in mammals and fungi.

Subject(s)

DNA, Mitochondrial/genetics , Mitochondria/genetics , Mitochondrial Proteins/genetics , Mitochondrial Ribosomes/ultrastructure , Protein Biosynthesis , Ribosome Subunits/ultrastructure , Animals , Anti-Bacterial Agents/pharmacology , Biological Evolution , Carboxylic Ester Hydrolases/genetics , Carboxylic Ester Hydrolases/metabolism , DNA, Mitochondrial/metabolism , Mammals , Mitochondria/metabolism , Mitochondrial Membranes/metabolism , Mitochondrial Proteins/metabolism , Mitochondrial Ribosomes/chemistry , Mitochondrial Ribosomes/metabolism , Models, Molecular , RNA, Messenger/genetics , RNA, Messenger/metabolism , RNA, Transfer/genetics , RNA, Transfer/metabolism , Ribosome Subunits/chemistry , Ribosome Subunits/metabolism , Saccharomyces cerevisiae/genetics , Saccharomyces cerevisiae/metabolism

ABSTRACT

Subject(s)

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