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1.
Epidemiol Infect ; 144(8): 1612-21, 2016 06.
Artículo en Inglés | MEDLINE | ID: mdl-26626237

RESUMEN

Linked administrative population data were used to estimate the burden of childhood respiratory syncytial virus (RSV) hospitalization in an Australian cohort aged <5 years. RSV-coded hospitalizations data were extracted for all children aged <5 years born in New South Wales (NSW), Australia between 2001 and 2010. Incidence was calculated as the total number of new episodes of RSV hospitalization divided by the child-years at risk. Mean cost per episode of RSV hospitalization was estimated using public hospital cost weights. The cohort comprised of 870 314 children. The population-based incidence/1000 child-years of RSV hospitalization for children aged <5 years was 4·9 with a rate of 25·6 in children aged <3 months. The incidence of RSV hospitalization (per 1000 child-years) was 11·0 for Indigenous children, 81·5 for children with bronchopulmonary dysplasia (BPD), 10·2 for preterm children with gestational age (GA) 32-36 weeks, 27·0 for children with GA 28-31 weeks, 39·0 for children with GA <28 weeks and 6·7 for term children with low birthweight. RSV hospitalization was associated with an average annual cost of more than AUD 9 million in NSW. RSV was associated with a substantial burden of childhood hospitalization specifically in children aged <3 months and in Indigenous children and children born preterm or with BPD.


Asunto(s)
Hospitalización/economía , Infecciones por Virus Sincitial Respiratorio/epidemiología , Infecciones por Virus Sincitial Respiratorio/patología , Virus Sincitiales Respiratorios/aislamiento & purificación , Preescolar , Femenino , Costos de la Atención en Salud , Humanos , Incidencia , Lactante , Recién Nacido , Almacenamiento y Recuperación de la Información , Masculino , Nueva Gales del Sur/epidemiología , Estudios Retrospectivos
2.
Mol Cell Endocrinol ; 578: 112049, 2023 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-37666445

RESUMEN

Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are oocyte-specific paracrine factors which regulate ovarian cumulus cell (CC) functions. This study aimed to investigate if BMP15 and GDF9 bound to CCs can be characterized, quantified, and show an association with IVF outcomes in infertile women. BMP15 and GDF9 ELISAs were validated and applied to discarded CC extracts. Pooled CCs from individual patients were collected from 120 (cohort 1; BMP15 only) and 81 infertility patients (cohort 2; BMP15 and GDF9) undergoing superovulation. BMP15 and GDF9 levels expressed per CC DNA were correlated with maternal age, clinical and embryology data. Total BMP15 and GDF9 were highly correlated with each other (r = 0.9, p < 0.001). The GDF9:BMP15 ratio was unrelated to oocyte number or age. BMP15/CC DNA and GDF9/CC DNA were unaffected by the type of superovulation and were not related to oocyte/embryo outcomes.

3.
J Gen Virol ; 91(Pt 8): 2062-2067, 2010 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-20392895

RESUMEN

Betapapillomaviruses (betaPVs) may contribute to the aetiology of cutaneous squamous cell carcinoma. However, no high-risk types have yet been identified, possibly because the high frequency of co-infection prevents a straightforward analysis of the independent effects of individual viruses. This study aimed to determine whether specific virus types were more likely to co-occur than others, thereby reducing the number of parameters needed in statistical models. Antibody data were analysed from controls who participated in case-control studies in The Netherlands, Italy and Australia and from participants in the German Nutrition Survey. Cluster analysis and two ordination techniques were used to identify patterns. Evidence of clustering was found only according to the number of viruses to which antibodies were detected. The lack of clustering of specific viral types identified suggests that if there are betaPV types that are independently related to skin carcinogenesis, they are unlikely to be identified using standard epidemiological methods.


Asunto(s)
Anticuerpos Antivirales/sangre , Betapapillomavirus/clasificación , Betapapillomavirus/aislamiento & purificación , Infecciones por Papillomavirus/epidemiología , Infecciones por Papillomavirus/virología , Adulto , Anciano , Anciano de 80 o más Años , Australia/epidemiología , Betapapillomavirus/inmunología , Estudios de Casos y Controles , Análisis por Conglomerados , Femenino , Alemania/epidemiología , Humanos , Italia/epidemiología , Masculino , Persona de Mediana Edad , Países Bajos/epidemiología , Prevalencia , Estudios Seroepidemiológicos
4.
Anaesth Intensive Care ; 38(1): 27-32, 2010 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20191773

RESUMEN

A postal survey was conducted to investigate difficult airway management, training and equipment availability among Fellows of the Australian and New Zealand College of Anaesthetists in Queensland. The survey aimed to determine practise patterns for predicted difficult airways and investigate equipment availability. Participants were asked to nominate an induction method, intubation method and airway adjunct for each of the five difficult airway scenarios. The cases consisted of one elective and four emergency scenarios. Availability of difficult airway devices in their institution was also assessed, as well as demographics of practice and airway-related maintenance of professional standards participation. There were 454 surveys distributed and 250 returned (response rate 55%). Direct laryngoscopy and flexible fibreoptic intubation were the most commonly selected techniques for all five cases. Difficult intubation trolleys were available to 98% of responders. Certain types of equipment (such as fibreoptic bronchoscopes and cricothyroidotomy kits) were available less frequently in private institutions. We recommend a standardisation of difficult airway management equipment and an on-going training program to provide support for anaesthetists in all locations.


Asunto(s)
Anestesia por Inhalación/instrumentación , Anestesia por Inhalación/métodos , Pautas de la Práctica en Medicina , Respiración Artificial/instrumentación , Respiración Artificial/métodos , Adulto , Australia , Servicios Médicos de Urgencia , Femenino , Encuestas de Atención de la Salud , Humanos , Intubación Intratraqueal/efectos adversos , Intubación Intratraqueal/instrumentación , Laringoscopios/provisión & distribución , Masculino , Persona de Mediana Edad , Encuestas y Cuestionarios
5.
Oncogene ; 29(11): 1653-62, 2010 Mar 18.
Artículo en Inglés | MEDLINE | ID: mdl-19966864

RESUMEN

There are two major molecular pathways to sporadic colorectal cancer, the chromosomal instability (CIN) and the CpG island methylator phenotype (CIMP) pathways. This study recruited 166 patients undergoing colonoscopy. Biopsy samples were collected from the cecum, transverse colon, sigmoid colon and rectum. DNA methylation was quantified at 'type A' (ESR1, GATA5, HIC1, HPP1, SFRP1) and 'type C' markers (MGMT, MLH1, CDKN2A, MINT2, MINT31, IGF2, CACNA1G, NEUROG1, SOCS1, RUNX3), and LINE-1. 'Type A' genes are frequently methylated in normal and neoplastic tissues, proportional to tissue age. 'Type C' methylation is more specific for neoplasia. The last five 'type C' markers comprise a CIMP panel. The mean 'type A' and CIMP-panel methylation Z-scores were calculated. In all, 88 patients had adenomatous lesions, 32 had proximal serrated polyps (PSPs) and 50 were normal. Most 'type A' genes showed direct correlations between methylation and age (ESR1, rho=0.66, P<0.0001), with higher methylation distally (ESR1, P<0.0001). On multivariate analysis, 'type A' methylation was inversely associated with colorectal adenomas (odds ratio=0.23, P<0.001), the precursor to CIN cancers. CIMP-panel methylation was significantly associated with advanced PSPs (odds ratio=5.1, P=0.009), the precursor to CIMP cancers. DNA methylation in normal mucosa varied with age and region and was associated with pathway-specific pathology. In the future, the colorectal field could yield important information and potentially inform clinical practice.


Asunto(s)
Neoplasias Colorrectales/genética , Metilación de ADN , Predisposición Genética a la Enfermedad/genética , Mucosa Intestinal/metabolismo , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Colon/metabolismo , Colonoscopía , Neoplasias Colorrectales/patología , Islas de CpG/genética , Femenino , Predisposición Genética a la Enfermedad/clasificación , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Recto/metabolismo , Factores Sexuales , Transducción de Señal/genética , Fumar , Adulto Joven
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