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Bioorg Med Chem Lett
; 23(4): 996-1000, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23312944
RESUMEN
Structure-activity relationship (SAR) of a novel, potent and metabolically stable series of benzo [3.2.1] bicyclic sulfonamide-pyrazoles as γ-secretase inhibitors are described. Compounds that are efficacious in reducing the cortical Aßx-40 levels in FVB mice via oral dose, as well as those with high selectivity over Notch, are highlighted.