1.
J Clin Virol
; 58(1): 321-4, 2013 Sep.
Article
in English
| MEDLINE
| ID: mdl-23731845
ABSTRACT
Herpes simplex virus type 1 (HSV-1) is a leading cause of corneal blindness. Acyclovir (ACV) constitutes the standard treatment of HSV infections including herpetic keratitis (HK). HSV resistance to ACV is mainly described in immunocompromised patients. We describe two cases of ACV-resistant corneal HSV-1 in immunocompetent individuals with recurrent HK.
Subject(s)
Acyclovir/therapeutic use , Antiviral Agents/therapeutic use , Drug Resistance, Viral , Herpesvirus 1, Human/genetics , Keratitis, Herpetic/drug therapy , Keratitis, Herpetic/virology , Acyclovir/pharmacology , Aged , Aged, 80 and over , Amino Acid Substitution , Antiviral Agents/pharmacology , DNA-Directed DNA Polymerase/genetics , Exodeoxyribonucleases/genetics , Herpesvirus 1, Human/drug effects , Herpesvirus 1, Human/isolation & purification , Humans , Male , Microbial Sensitivity Tests , Mutant Proteins/genetics , Mutation, Missense , Recurrence , Thymidine Kinase/genetics , Viral Proteins/genetics
2.
J Clin Virol
; 56(2): 175-6, 2013 Feb.
Article
in English
| MEDLINE
| ID: mdl-23177166