[Rehabilitation therapy of convalescents after hemorrhagic fever with renal syndrome in outpatient clinic]. / Vosstanovitel'noe lechenie v usloviiakh polikliniki rekonvalestsentov, perenesshikh gemorragicheskuiu likhoradku s pochechnym simdromom.

AIM: To assess clinical efficacy of mineral water and perindopril in convalescents after hemorrhagic fever with renal syndrome (HFRS) in outpatient setting. MATERIAL AND METHODS: The study covered 113 HFRS convalescents. HFRS was confirmed serologically. The patients were divided into three groups: group 1 (n = 50) received no rehabilitation care; group 2 (n = 32) drank mineral water "varzi-yatchi"; group 3 (n = 31) drank mineral water and took perindopril (2 mg/day). After-treatment continued for 30-35 days. The effect was assessed by a complex of clinical-laboratory and functional tests for examination of renal functions (Reberg-Tareev, Zimnitsky tests, estimation of uric acid clearance and renal functional reserve, an 18-hour water deprivation test). RESULTS: Mineral water varzi-yatchi and perindopril had a favourable effect on clinical condition and renal functions of HFRS convalescents. Compared to the controls (p < 0.05), they had less severe weakness, lumbar pains, edema of the lower limbs; positive changes in intraglomerular hemodynamics, renal transport of beta 2-microglobulin (MG), uric acid transport. CONCLUSION: It is shown that HFRS convalescents have defective glomerular and tubulointerstitial systems of the kidneys. These disorders demand a differential therapeutic approach. Drinking mineral water improves some tubular functions. The addition of perindopril is necessary in detection of arterial hypertension, impairment of intraglomerular hemodynamics, hyperexcretion of beta 2-MG, osmoregulating renal dysfunction.

[Effect of adjuvant magnesium therapy on the quality of life and emotional status of elderly patients with stable angina]. / Vliianie soprovoditel'noi magnieterapii na kachestvo zhizni i émotsional'nyi status pozhilykh bol'nykh so stabil'noi stenokardiei.

The difficulties of treatment of the chronic coronar syndrome in the elderly patients depends on the severity of the disease and multimorbidity. Administration of magnesium preparations in these patients compensates the sytemic magnesium deficit. A number of physiological effects of magnesium allows to potentiate the antianginal effect of background drugs. The study of quality of life and of psychoemotional status in elderly patients with stable angina during the treatment with magnesium has been performed. It was observed an initial decrease of quality of life accompanied by anxiety and subdepressive emotional features. Adjuvant therapy with Magnerot and magnesium sulphate was followed by significant improvement in parameters of quality of life and by positive changes in psychoemotional status of patients.