RESUMEN
BACKGROUND: To assess the effects of treatment with nebulized corticosteroids immediately after chlorine gas injury. METHODS: Eighteen anesthetized and mechanically ventilated pigs were exposed to chlorine gas (140 ppm for 10 minutes) and observed for 6 hours. Nine pigs were treated with nebulized beclomethasone-dipropionate 20 microg/kg (BDP group), and nine pigs were given no treatment (control group). RESULTS: All animals developed severe pulmonary dysfunction. The initial decrease in PaO2 was similar in both groups, but BDP-treated animals improved whereas control animals deteriorated (p < 0.005; analysis of variance). Pulmonary vascular resistance increased in both groups but less in the BDP group (p < 0.01). Lung-thorax compliance was better preserved in the BDP group (p < 0.01), and oxygen delivery was significantly better in the BDP group (p < 0.01). One animal died in the BDP group, as did three animals in the control group. CONCLUSION: Immediate treatment with nebulized BDP improved pulmonary and cardiovascular function after experimental chlorine gas injury.
Asunto(s)
Antiinflamatorios/uso terapéutico , Beclometasona/uso terapéutico , Cloro/efectos adversos , Gases/efectos adversos , Edema Pulmonar/inducido químicamente , Edema Pulmonar/tratamiento farmacológico , Administración por Inhalación , Aerosoles , Análisis de Varianza , Animales , Antiinflamatorios/farmacología , Beclometasona/farmacología , Análisis de los Gases de la Sangre , Modelos Animales de Enfermedad , Evaluación Preclínica de Medicamentos , Monitoreo de Drogas , Hemodinámica/efectos de los fármacos , Rendimiento Pulmonar/efectos de los fármacos , Circulación Pulmonar/efectos de los fármacos , Edema Pulmonar/patología , Edema Pulmonar/fisiopatología , Respiración Artificial , Porcinos , Resistencia Vascular/efectos de los fármacosRESUMEN
Many people experience problems with a dry nasal mucous membrane, often without wondering why. Their noses itch and burn and dried mucus collects there. These problems are exacerbated during the winter, in air-conditioned environments and after nasal irradiation. Twenty patients experiencing problems with dryness of the nose were selected from outpatient clinics, together with twenty patients who had previously undergone nasal irradiation. During the first five days no treatment was administered. For the following twenty days the patients sprayed sesame oil into each nostril three times a day. For the last five days no treatment was given. When both groups received treatment and sprayed sesame oil (Nozoil) in their noses, the nasal problems decreased significantly. The greatest effect is exerted on dryness. The side effects from using this oil are few in number and mild.
Asunto(s)
Mucosa Nasal/efectos de los fármacos , Mucosa Nasal/metabolismo , Enfermedades Nasales/tratamiento farmacológico , Aceite de Sésamo/administración & dosificación , Administración Intranasal , Adulto , Anciano , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Mucosa Nasal/efectos de la radiación , Enfermedades Nasales/diagnóstico , Enfermedades Nasales/etiología , Resultado del TratamientoAsunto(s)
Estado de Conciencia , Intubación , Anestesia Local , Humanos , Intubación/métodos , Neoplasias Laríngeas/cirugíaRESUMEN
The three substances bromhexine, NA 872 (bromhexine metabolite VIII) and the beta 2-receptor agonist NAB 365 (clenbuterol) and their effect on the mucociliary activity have been studied in vivo in rabbits. The substances were given parenterally in increasing dosages and 519 records were obtained from 12 rabbits. Not even at dosages in excess of recommended human dosages has any effect on the mucociliary activity been observed for any of the substances during the first 30 minutes after administration. The conclusion to be drawn is that the three substances have no effect on the mucociliary activity in rabbit in vivo, but that this does not exclude an effect on mucociliary transport or clearance.