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Métodos Terapéuticos y Terapias MTCI
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1.
J Food Drug Anal ; 27(1): 275-283, 2019 01.
Artículo en Inglés | MEDLINE | ID: mdl-30648581

RESUMEN

Wu Ji Bai Feng Pill (WJBFP) is a traditional Chinese medicine (TCM) complex formula, which has been widely used in the treatment of various gynecological disorders. However, the quality control of multiple components in WJBFP is challengeable by using the methods applicable to analysis of several phytochemicals in single herbs or simple herbal preparations. The purpose of this study is to establish an ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-MS/MS) method for the quantitative determination of 20 bioactive compounds in WJBFP. The modified chromatographic conditions were achieved on an Agilent Poroshell 120 EC-C18 column with a gradient elution consisted of 0.1% formic acid in acetonitrile and 0.1% aqueous formic acid (v/v). All analytes were determined using a triple quadrupole mass spectrometry in positive or negative ionization modes with multiple reaction monitoring (MRM) mode. An UHPLC-MS/MS method was optimized and validated for linearity, limits of detection and quantification, precision, repeatability, stability and recovery. The proposed method was applied for the analysis of 20 compounds in 19 batches of commercial WJBFP products. principal component analysis and hierarchical cluster analysis were applied to evaluate intrinsic quality and to identify chemical markers most responsible for quality evaluation. In conclusion, the established method offered speedy and sensitive determination for 20 compounds and is helpful for chemical standardization of commercial WJBFP products.


Asunto(s)
Cromatografía Líquida de Alta Presión/métodos , Medicamentos Herbarios Chinos/química , Espectrometría de Masas en Tándem/métodos , Límite de Detección , Medicina Tradicional China , Análisis Multivariante , Análisis de Componente Principal
2.
Eur J Oncol Nurs ; 34: 1-7, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29784132

RESUMEN

PURPOSE: Enhancing self-efficacy during the active cycle of breathing technique is essential for realizing the full benefit of pulmonary rehabilitation among lung cancer patients. This study aimed to explore the effect of self-efficacy-enhancing active cycle of breathing technique (SEE-ACBT) among patients with lung resection. METHOD: A quasi-experimental trial with a pre-post test design was performed. The control group (n = 81) received routine perioperative care, and the intervention group (n = 81) received SEE-ACBT in addition to routine perioperative care. The primary outcome measure was 24-h wet sputum weight. Other outcomes included the 6-min walk test (6MWT), Borg scale, postoperative pulmonary complications (PPC), exercise self-efficacy, hospitalization cost, duration of oxygen inhalation, and days of postoperative hospital stay. RESULTS: The sputum weight in the intervention group gradually increased from postoperative day 1, day 2, to day 3 and was significantly higher than that of the control group on day 2 and day 3 (P = 0.000). An average of ¥5047 (US$ 767.6) in hospitalization costs was saved in the intervention group (P = 0.003). Exercise self-efficacy (79. 0 VS 71.7,P = 0.006), 6MWT (471.8 m VS 371.6 m,P = 0.000), and duration of oxygen inhalation (33.9 h VS 53.1 h, P = 0.000) among patients in the intervention group improved significantly compared with the control group. No significant differences in PPC and days of postoperative hospital stay were found. CONCLUSIONS: SEE-ACBT is an effective and economical short-term pulmonary rehabilitation method. Pulmonary rehabilitation should focus on increasing motivational behaviours. Further studies should be implemented to explore the long-term effects of SEE-ACBT.


Asunto(s)
Ejercicios Respiratorios/métodos , Ejercicios Respiratorios/psicología , Neoplasias Pulmonares/cirugía , Complicaciones Posoperatorias/rehabilitación , Terapia Respiratoria/métodos , Autoeficacia , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad
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