28-day Repeated Dose Oral Toxicity Test of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats / 日本補完代替医療学会誌

<i>Coix lacryma-jobi </i>L. var<i>.ma-yuen</i> Stapf (coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of coix seed has rarely been evaluated. We performed a 28-day repeated dose oral toxicity test of hot water extract of all parts of Coix seed in rats. The extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.<br>

Mutagenicity Test for Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf-Reverse Mutation Test, Mouse Lymphoma Assay (MLA) and Mouse Micronucleus Test / 日本補完代替医療学会誌

<i>Coix lacryma-jobi</i> L. <i>var. ma-yuen</i> Stapf is a grass long been used in traditional medicine as a nourishing food and reported to possess pharmacological effects including anti-tumor, anti-obesity, anti-diabetic, etc. In order to evaluate the possible mutagenicity of the hot water extract of all parts (husks, pellicles, and astringent skin) of the food, we performed a reverse mutation test in bacteria, a mouse lymphoma assay and a mouse micronucleus test. The results of all tests were negative. It was concluded that the extract has no mutagenicity for living bodies.<br>