RESUMO
ABSTRACT: Surface treatment of medical devices may be a way of avoiding the need for replacement of these devices and the comorbidities associated with infection. The aim of this study was to evaluate whether pre- and postcontamination washing of 2 prostheses with different textures can decrease bacterial contamination.The following microorganisms were evaluated: Staphylococcus aureus, Staphylococcus epidermidis, Proteus mirabilis and Enterococcus faecalis. Silicone and expanded polytetrafluoroethylene vascular prostheses were used and divided into 3 groups: prostheses contaminated; prostheses contaminated and treated before contamination; and prostheses contaminated and treated after contamination. Treatments were performed with antibiotic solution, chlorhexidine and lidocaine. After one week of incubation, the prostheses were sown in culture medium, which was incubated for 48âhours. The area of colony formation was evaluated by fractal dimension, an image analysis tool.The antibiotic solution inhibited the growth of S epidermidis and chlorhexidine decrease in 53% the colonization density for S aureus in for both prostheses in the pre-washing. In postcontamination washing, the antibiotic solution inhibited the growth of all bacteria evaluated; there was a 60% decrease in the colonization density of S aureus and absence of colonization for E faecalis with chlorhexidine; and lidocaine inhibited the growth of S aureus in both prostheses.Antibiotic solution showed the highest efficiency in inhibiting bacterial growth, especially for S epidermidis, in both washings. Lidocaine was able to reduce colonization by S aureus in post-contamination washing, showing that it can be used as an alternative adjuvant treatment in these cases.
Assuntos
Prótese Vascular/microbiologia , Descontaminação/métodos , Desinfetantes/administração & dosagem , Infecções Relacionadas à Prótese/prevenção & controle , Antibacterianos/administração & dosagem , Contagem de Colônia Microbiana , Enterococcus faecalis/crescimento & desenvolvimento , Humanos , Lidocaína/administração & dosagem , Politetrafluoretileno , Desenho de Prótese , Infecções Relacionadas à Prótese/microbiologia , Proteus mirabilis/crescimento & desenvolvimento , Silicones , Staphylococcus aureus/crescimento & desenvolvimento , Staphylococcus epidermidis/crescimento & desenvolvimentoRESUMO
A 28-year-old white female patient presented with multiple erythematous-to-violaceous, painful, suppurative nodules on the buttocks and thighs that appeared after two weeks of mesotherapy with deoxycholate, caffeine, sunflower liposomes, and sinetrol for localized fat. She was treated for atypical mycobacteriosis, but with no satisfactory response after antibiotic therapy. Bacterial, mycobacterial, and fungal culture were all negative. Histopathologic examination of the biopsy showed noninfectious suppurative panniculitis. It resolved after treatment with methotrexate, prednisone, and hydroxychloroquine. This report highlights the rarity of this complication, the importance of its early recognition, and differentiation with atypical fast growing mycobacterioses.
Assuntos
Ácido Desoxicólico/efeitos adversos , Mesoterapia/efeitos adversos , Paniculite Nodular não Supurativa/induzido quimicamente , Paniculite Nodular não Supurativa/patologia , Adulto , Biópsia , Derme/patologia , Feminino , Humanos , Paniculite Nodular não Supurativa/tratamento farmacológico , Resultado do TratamentoRESUMO
Abstract A 28-year-old white female patient presented with multiple erythematous-to-violaceous, painful, suppurative nodules on the buttocks and thighs that appeared after two weeks of mesotherapy with deoxycholate, caffeine, sunflower liposomes, and sinetrol for localized fat. She was treated for atypical mycobacteriosis, but with no satisfactory response after antibiotic therapy. Bacterial, mycobacterial, and fungal culture were all negative. Histopathologic examination of the biopsy showed noninfectious suppurative panniculitis. It resolved after treatment with methotrexate, prednisone, and hydroxychloroquine. This report highlights the rarity of this complication, the importance of its early recognition, and differentiation with atypical fast growing mycobacterioses.
Assuntos
Humanos , Feminino , Adulto , Paniculite Nodular não Supurativa/induzido quimicamente , Paniculite Nodular não Supurativa/patologia , Ácido Desoxicólico/efeitos adversos , Mesoterapia/efeitos adversos , Biópsia , Paniculite Nodular não Supurativa/tratamento farmacológico , Resultado do Tratamento , Derme/patologiaRESUMO
A case of a squamous cell carcinoma of the conjunctiva is presented. The lesion was removed with recurrence in another conjunctival site. The patient received cycles of 5-Fluorouracil as adjuvant treatment to the surgical removal and presented unfavorable evolution, requiring orbital exenteration. Comments are made on the use of antimitotic drugs in the management of these lesions.
Assuntos
Carcinoma de Células Escamosas/terapia , Neoplasias da Túnica Conjuntiva/terapia , Exenteração Orbitária , Neoplasias Orbitárias/terapia , Idoso , Antimetabólitos Antineoplásicos/uso terapêutico , Carcinoma de Células Escamosas/patologia , Terapia Combinada/métodos , Neoplasias da Túnica Conjuntiva/patologia , Fluoruracila/uso terapêutico , Humanos , Masculino , Recidiva Local de Neoplasia , Neoplasias Orbitárias/patologiaRESUMO
Portador de carcinoma espinocelular da conjuntiva teve a lesão removida, com recorrência em outra localização. O paciente recebeu ciclos de 5-Fluoruracila como tratamento adjuvante à remoção cirúrgica, apresentando evolução desfavorável que chegou à exenteração orbitária. São feitos comentários quanto ao uso de antimitóticos no tratamento destas lesões.
A case of a squamous cell carcinoma of the conjunctiva is presented. The lesion was removed with recurrence in another conjunctival site. The patient received cycles of 5-Fluorouracil as adjuvant treatment to the surgical removal and presented unfavorable evolution, requiring orbital exenteration. Comments are made on the use of antimitotic drugs in the management of these lesions.
Assuntos
Idoso , Humanos , Masculino , Carcinoma de Células Escamosas/terapia , Neoplasias da Túnica Conjuntiva/terapia , Exenteração Orbitária , Neoplasias Orbitárias/terapia , Antimetabólitos Antineoplásicos/uso terapêutico , Carcinoma de Células Escamosas/patologia , Terapia Combinada/métodos , Neoplasias da Túnica Conjuntiva/patologia , Fluoruracila/uso terapêutico , Recidiva Local de Neoplasia , Neoplasias Orbitárias/patologiaRESUMO
Os autores apresentaram um caso de paracoccidioidomicose subaguda progressiva acometendo gânglios mesentéricos, cujo diagnóstico etiológico foi realizado por meio de laparotomia exploradora. Devido as más condiçöes do doente no pós-operatório e presença de suboclusäo intestinal, foi optado pelo tratamento antifúngico específico a base de cotrimoxazole (associaçäo sulfametoxazol e trimetoprim), associado a nutriçäo parenteral total. Os autores discutem a interaçäo nutriçäo-infecçäo-imunidade e sugerem que em doentes onde há importante comprometimento do tubo digestivo pela micose, acompanhado de suboclusäo intestinal ou abdome agudo, a nutriçäo parenteral total como terapêutica coadjuvante contribui sobremaneira para melhorar o prognóstico do doente