RESUMO
With increasing number of immunocompromised patients as well as drug resistance in fungi, the risk of fatal fungal infections in humans increases as well. The action of echinocandins is based on the inhibition of ß-(1,3)-d-glucan synthesis that builds the fungal cell wall. Caspofungin, micafungin, anidulafungin and rezafungin are semi-synthetic cyclic lipopeptides. Their specific chemical structure possess a potential to obtain novel derivatives with better pharmacological properties resulting in more effective treatment, especially in infections caused by Candida and Aspergillus species. In this review we summarise information about echinocandins with closer look on their chemical structure, mechanism of action, drug resistance and usage in clinical practice. We also introduce actual trends in modification of this antifungals as well as new methods of their administration, and additional use in viral and bacterial infections.
Assuntos
Antifúngicos/farmacologia , Aspergillus/efeitos dos fármacos , Candida/efeitos dos fármacos , Desenho de Fármacos , Equinocandinas/farmacologia , Antifúngicos/química , Aspergillus/metabolismo , Candida/metabolismo , Parede Celular/efeitos dos fármacos , Parede Celular/metabolismo , Equinocandinas/química , Glucanos/antagonistas & inibidores , Glucanos/metabolismo , Testes de Sensibilidade Microbiana , Estrutura MolecularRESUMO
BACKGROUND: A growing body of evidence supports the belief that yoga benefits physical and mental health. The aim of the study is to investigate whether the sense of coherence and sense of agency are more developed in people practicing hatha-yoga than in the group of people who have never practiced yoga. METHODS: TAHE, SOC-29 questionnaire and short microphenomenological interview conducted on a group of 15 people (8 yoga instructors, 7 in the control group). RESULTS: It has been shown that the study group has significantly higher scores in both the sense of agency and sense of coherence than the control group. In addition, a statistically significant correlation was observed between the part of the values mentioned above. CONCLUSIONS: There are indications that the hatha-yoga exercise increases the sense of agency, which in the long run can contribute to better mental health. In order to find a clear and certain link between the sense of coherence and the sense of agency additional research is necessary.