1.
J Nat Prod
; 59(9): 839-42, 1996 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8864237
RESUMO
Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.