RESUMO
The main strategies for the design of telechelic polymers synthesized by reversible-activation radical polymerization for biomedical applications are covered spanning from drug delivery and targeting to theranostics and sensing.
Assuntos
Polímeros/química , Animais , Portadores de Fármacos/síntese química , Portadores de Fármacos/química , Portadores de Fármacos/farmacologia , Corantes Fluorescentes/síntese química , Corantes Fluorescentes/química , Corantes Fluorescentes/farmacologia , Humanos , Camundongos , Polimerização , Polímeros/síntese química , Polímeros/farmacologiaRESUMO
We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] ( and ) in Pluronic® triblock copolymer P123 core-shell micelles. The spherical nanoparticles and , dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes and were highly active towards A2780 human ovarian cancer cells (IC(50) 0.17 and 2.50 µM, respectively) and the encapsulated complexes, as and nanoparticles, were less potent (IC(50) 6.69 µM and 117.5 µM, respectively), but more selective towards cancer cells compared to normal cells.