RESUMEN
OBJECTIVE: To explore biomolecular characteristics of a group of patients with nasopharyngeal carcinoma from European (Spanish) hospitals, addressing the pathogenesis of the tumor and the response to treatment. STUDY DESIGN: Cyclin D1 and p16 expression were evaluated immunohistochemically in 33 tissue samples of nasopharyngeal carcinoma. CCDN1 gene amplification and p16 gene deletion were studied by fluorescence in situ hybridization. Patient clinical data were examined, and tissues were evaluated histologically using hematoxylin-eosin staining. RESULTS: Cyclin D1 overexpression was found in 19 cases, and p16 expression was undetected in 30 cases. An association was observed between impaired p16 expression and cyclin D1 overexpression (p = 0.034). Eleven patients displayed p16 gene deletion and CCDN1 gene amplification. CONCLUSION: Cyclin D1 overexpression and CCDN1 amplification, loss of p16 expression and p16 deletion may be among the genetic alterations involved in the pathogenesis of nasopharyngeal carcinoma.
Asunto(s)
Ciclina D1/genética , Inhibidor p16 de la Quinasa Dependiente de Ciclina/genética , Neoplasias Nasofaríngeas/genética , Adulto , Anciano , Inhibidor p16 de la Quinasa Dependiente de Ciclina/metabolismo , Femenino , Humanos , Inmunohistoquímica , Hibridación Fluorescente in Situ , Masculino , Persona de Mediana Edad , Neoplasias Nasofaríngeas/diagnóstico , Estudios Retrospectivos , EspañaRESUMEN
El fibroxantoma atípico es un tumor mesenquimal consideradouna variante superficial del histiocitoma fibrosomaligno asociado con un buen pronóstico. La variante decélulas claras es una de las más infrecuentes y debería serdiferenciada de otras neoplasias de células claras cutáneas,en particular de metástasis de tumores de órganos internossobre todo carcinoma de origen renal. Es importante hacerénfasis en esta distintiva e inhabitual neoplasia para así evitarfalsos diagnósticos y terapias inapropiadas (AU)
Atypical fibroxanthoma is a mesenchimal tumour that isconsidered a superficial variant of malignant fibrous histiocytomaassociated with a good prognosis. Among therarest variants is the clear-cell atypical fibroxanthoma, thatshould be differentiated from other clear-cell neoplasms ofthe skin and in particular cutaneous metastasis from neoplasmsfrom internal organs, including renal cell carcinoma.We hope to alert pathologists to this distinctive and unusualneoplasm to avoid under- or over-diagnosis and inappropriatetherapy (AU)
Asunto(s)
Humanos , Femenino , Anciano , Histiocitoma Fibroso Maligno/diagnóstico , Histiocitoma Fibroso Maligno/patología , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patología , Diagnóstico Diferencial , InmunohistoquímicaRESUMEN
El nódulo angiomatoso epitelioide cutáneo (NAEC), esuna lesión vascular recientemente descrita que muestrahallazgos histológicos distintivos y un curso evolutivobenigno. Clínicamente suele presentarse como un nódulo opápula eritematosa de reciente aparición, predominantementelocalizados en tronco y extremidades; y a pesar, delas aparentes diferencias clínico-patológicas, no es posiblecon certeza descartar que pueda tratarse de una variantepoco usual de hemangioma epitelioide (HE)
Cutaneous epithelioid angiomatous nodule (CEAN), is arecently described vascular lesion with distinct histologicalfeatures and apparently benign behaviour. The lesion is predominantlylocated in the trunk and extremities. It appearsas a small erythematous papule or nodule with a short history.Despite the apparent clinicopathologic differences, thepossibility that CEAN represent a very unusual variant ofepithelioid hemangioma can not absolutely be excluded