Search | VHL Search Portal

1.

Molecular basis of opioid receptor signaling.

Che, Tao; Roth, Bryan L.

Cell ; 186(24): 5203-5219, 2023 11 22.

Article in English | MEDLINE | ID: mdl-37995655

2.

Structural Insights Accelerate the Discovery of Opioid Alternatives.

Che, Tao; Roth, Bryan L.

Annu Rev Biochem ; 90: 739-761, 2021 06 20.

Article in English | MEDLINE | ID: mdl-33756098

3.

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT_2A Serotonin Receptor.

Kim, Kuglae; Che, Tao; Panova, Ouliana; DiBerto, Jeffrey F; Lyu, Jiankun; Krumm, Brian E; Wacker, Daniel; Robertson, Michael J; Seven, Alpay B; Nichols, David E; Shoichet, Brian K; Skiniotis, Georgios; Roth, Bryan L.

Cell ; 182(6): 1574-1588.e19, 2020 09 17.

Article in English | MEDLINE | ID: mdl-32946782

4.

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Che, Tao; Majumdar, Susruta; Zaidi, Saheem A; Ondachi, Pauline; McCorvy, John D; Wang, Sheng; Mosier, Philip D; Uprety, Rajendra; Vardy, Eyal; Krumm, Brian E; Han, Gye Won; Lee, Ming-Yue; Pardon, Els; Steyaert, Jan; Huang, Xi-Ping; Strachan, Ryan T; Tribo, Alexandra R; Pasternak, Gavril W; Carroll, F Ivy; Stevens, Raymond C; Cherezov, Vadim; Katritch, Vsevolod; Wacker, Daniel; Roth, Bryan L.

Cell ; 172(1-2): 55-67.e15, 2018 01 11.

Article in English | MEDLINE | ID: mdl-29307491

5.

5-HT_2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng, Yao; McCorvy, John D; Harpsøe, Kasper; Lansu, Katherine; Yuan, Shuguang; Popov, Petr; Qu, Lu; Pu, Mengchen; Che, Tao; Nikolajsen, Louise F; Huang, Xi-Ping; Wu, Yiran; Shen, Ling; Bjørn-Yoshimoto, Walden E; Ding, Kang; Wacker, Daniel; Han, Gye Won; Cheng, Jianjun; Katritch, Vsevolod; Jensen, Anders A; Hanson, Michael A; Zhao, Suwen; Gloriam, David E; Roth, Bryan L; Stevens, Raymond C; Liu, Zhi-Jie.

Cell ; 172(4): 719-730.e14, 2018 02 08.

Article in English | MEDLINE | ID: mdl-29398112

6.

Crystal Structure of an LSD-Bound Human Serotonin Receptor.

Wacker, Daniel; Wang, Sheng; McCorvy, John D; Betz, Robin M; Venkatakrishnan, A J; Levit, Anat; Lansu, Katherine; Schools, Zachary L; Che, Tao; Nichols, David E; Shoichet, Brian K; Dror, Ron O; Roth, Bryan L.

Cell ; 168(3): 377-389.e12, 2017 01 26.

Article in English | MEDLINE | ID: mdl-28129538

7.

Ligand efficacy modulates conformational dynamics of the µ-opioid receptor.

Zhao, Jiawei; Elgeti, Matthias; O'Brien, Evan S; Sár, Cecília P; Ei Daibani, Amal; Heng, Jie; Sun, Xiaoou; White, Elizabeth; Che, Tao; Hubbell, Wayne L; Kobilka, Brian K; Chen, Chunlai.

Nature ; 629(8011): 474-480, 2024 May.

Article in English | MEDLINE | ID: mdl-38600384

8.

Ligand and G-protein selectivity in the κ-opioid receptor.

Han, Jianming; Zhang, Jingying; Nazarova, Antonina L; Bernhard, Sarah M; Krumm, Brian E; Zhao, Lei; Lam, Jordy Homing; Rangari, Vipin A; Majumdar, Susruta; Nichols, David E; Katritch, Vsevolod; Yuan, Peng; Fay, Jonathan F; Che, Tao.

Nature ; 617(7960): 417-425, 2023 05.

Article in English | MEDLINE | ID: mdl-37138078

9.

Structure-based design of bitopic ligands for the µ-opioid receptor.

Faouzi, Abdelfattah; Wang, Haoqing; Zaidi, Saheem A; DiBerto, Jeffrey F; Che, Tao; Qu, Qianhui; Robertson, Michael J; Madasu, Manish K; El Daibani, Amal; Varga, Balazs R; Zhang, Tiffany; Ruiz, Claudia; Liu, Shan; Xu, Jin; Appourchaux, Kevin; Slocum, Samuel T; Eans, Shainnel O; Cameron, Michael D; Al-Hasani, Ream; Pan, Ying Xian; Roth, Bryan L; McLaughlin, Jay P; Skiniotis, Georgios; Katritch, Vsevolod; Kobilka, Brian K; Majumdar, Susruta.

Nature ; 613(7945): 767-774, 2023 01.

Article in English | MEDLINE | ID: mdl-36450356

10.

Bespoke library docking for 5-HT_2A receptor agonists with antidepressant activity.

Kaplan, Anat Levit; Confair, Danielle N; Kim, Kuglae; Barros-Álvarez, Ximena; Rodriguiz, Ramona M; Yang, Ying; Kweon, Oh Sang; Che, Tao; McCorvy, John D; Kamber, David N; Phelan, James P; Martins, Luan Carvalho; Pogorelov, Vladimir M; DiBerto, Jeffrey F; Slocum, Samuel T; Huang, Xi-Ping; Kumar, Jain Manish; Robertson, Michael J; Panova, Ouliana; Seven, Alpay B; Wetsel, Autumn Q; Wetsel, William C; Irwin, John J; Skiniotis, Georgios; Shoichet, Brian K; Roth, Bryan L; Ellman, Jonathan A.

Nature ; 610(7932): 582-591, 2022 10.

Article in English | MEDLINE | ID: mdl-36171289

11.

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms.

Stein, Reed M; Kang, Hye Jin; McCorvy, John D; Glatfelter, Grant C; Jones, Anthony J; Che, Tao; Slocum, Samuel; Huang, Xi-Ping; Savych, Olena; Moroz, Yurii S; Stauch, Benjamin; Johansson, Linda C; Cherezov, Vadim; Kenakin, Terry; Irwin, John J; Shoichet, Brian K; Roth, Bryan L; Dubocovich, Margarita L.

Nature ; 579(7800): 609-614, 2020 03.

Article in English | MEDLINE | ID: mdl-32040955

12.

Insights into distinct signaling profiles of the µOR activated by diverse agonists.

Qu, Qianhui; Huang, Weijiao; Aydin, Deniz; Paggi, Joseph M; Seven, Alpay B; Wang, Haoqing; Chakraborty, Soumen; Che, Tao; DiBerto, Jeffrey F; Robertson, Michael J; Inoue, Asuka; Suomivuori, Carl-Mikael; Roth, Bryan L; Majumdar, Susruta; Dror, Ron O; Kobilka, Brian K; Skiniotis, Georgios.

Nat Chem Biol ; 19(4): 423-430, 2023 04.

Article in English | MEDLINE | ID: mdl-36411392

13.

Ultra-large library docking for discovering new chemotypes.

Lyu, Jiankun; Wang, Sheng; Balius, Trent E; Singh, Isha; Levit, Anat; Moroz, Yurii S; O'Meara, Matthew J; Che, Tao; Algaa, Enkhjargal; Tolmachova, Kateryna; Tolmachev, Andrey A; Shoichet, Brian K; Roth, Bryan L; Irwin, John J.

Nature ; 566(7743): 224-229, 2019 02.

Article in English | MEDLINE | ID: mdl-30728502

14.

Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.

Wang, Sheng; Che, Tao; Levit, Anat; Shoichet, Brian K; Wacker, Daniel; Roth, Bryan L.

Nature ; 555(7695): 269-273, 2018 03 08.

Article in English | MEDLINE | ID: mdl-29466326

15.

Enhancing Leaf Area Index Estimation for Maize with Tower-Based Multi-Angular Spectral Observations.

Yan, Lieshen; Liu, Xinjie; Jing, Xia; Geng, Liying; Che, Tao; Liu, Liangyun.

Sensors (Basel) ; 23(22)2023 Nov 11.

Article in English | MEDLINE | ID: mdl-38005509

16.

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome.

Olsen, Reid H J; DiBerto, Jeffrey F; English, Justin G; Glaudin, Alexis M; Krumm, Brian E; Slocum, Samuel T; Che, Tao; Gavin, Ariana C; McCorvy, John D; Roth, Bryan L; Strachan, Ryan T.

Nat Chem Biol ; 16(8): 841-849, 2020 08.

Article in English | MEDLINE | ID: mdl-32367019

17.

Satellite-Enabled Internet of Remote Things Network Transmits Field Data from the Most Remote Areas of the Tibetan Plateau.

Chen, Yingying; Zhang, Minghu; Li, Xin; Che, Tao; Jin, Rui; Guo, Jianwen; Yang, Wei; An, Baosheng; Nie, Xiaowei.

Sensors (Basel) ; 22(10)2022 May 13.

Article in English | MEDLINE | ID: mdl-35632122

18.

Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain.

El Daibani, Amal; Che, Tao.

Molecules ; 27(3)2022 Jan 18.

Article in English | MEDLINE | ID: mdl-35163856

19.

Advances in the Treatment of Chronic Pain by Targeting GPCRs.

Che, Tao.

Biochemistry ; 60(18): 1401-1412, 2021 05 11.

Article in English | MEDLINE | ID: mdl-33186495

20.

Predicted Mode of Binding to and Allosteric Modulation of the µ-Opioid Receptor by Kratom's Alkaloids with Reported Antinociception In Vivo.

Zhou, Yuchen; Ramsey, Steven; Provasi, Davide; El Daibani, Amal; Appourchaux, Kevin; Chakraborty, Soumen; Kapoor, Abhijeet; Che, Tao; Majumdar, Susruta; Filizola, Marta.

Biochemistry ; 60(18): 1420-1429, 2021 05 11.

Article in English | MEDLINE | ID: mdl-33274929

VHL Search Portal

Information and Knowledge for Health

Config filters

Your selection (0)

Export format:

Export: