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1.

Enzymatic and non-enzymatic transnitrosylation: "SCAN"ning the SNO-proteome.

Nakamura, Tomohiro; Lipton, Stuart A.

Mol Cell ; 84(2): 191-193, 2024 Jan 18.

Article in English | MEDLINE | ID: mdl-38242098

2.

Partnering with Big Pharma-What Academics Need to Know.

Lipton, Stuart A; Nordstedt, Christer.

Cell ; 165(3): 512-5, 2016 Apr 21.

Article in English | MEDLINE | ID: mdl-27104971

3.

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.

Xian, Hongxu; Liu, Yuan; Rundberg Nilsson, Alexandra; Gatchalian, Raphaella; Crother, Timothy R; Tourtellotte, Warren G; Zhang, Yi; Aleman-Muench, German R; Lewis, Gavin; Chen, Weixuan; Kang, Sarah; Luevanos, Melissa; Trudler, Dorit; Lipton, Stuart A; Soroosh, Pejman; Teijaro, John; de la Torre, Juan Carlos; Arditi, Moshe; Karin, Michael; Sanchez-Lopez, Elsa.

Immunity ; 54(7): 1463-1477.e11, 2021 07 13.

Article in English | MEDLINE | ID: mdl-34115964

4.

Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.

Ryan, Scott D; Dolatabadi, Nima; Chan, Shing Fai; Zhang, Xiaofei; Akhtar, Mohd Waseem; Parker, James; Soldner, Frank; Sunico, Carmen R; Nagar, Saumya; Talantova, Maria; Lee, Brian; Lopez, Kevin; Nutter, Anthony; Shan, Bing; Molokanova, Elena; Zhang, Yaoyang; Han, Xuemei; Nakamura, Tomohiro; Masliah, Eliezer; Yates, John R; Nakanishi, Nobuki; Andreyev, Aleksander Y; Okamoto, Shu-ichi; Jaenisch, Rudolf; Ambasudhan, Rajesh; Lipton, Stuart A.

Cell ; 155(6): 1351-64, 2013 Dec 05.

Article in English | MEDLINE | ID: mdl-24290359

5.

Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.

Cabral-Miranda, Felipe; Tamburini, Giovanni; Martinez, Gabriela; Ardiles, Alvaro O; Medinas, Danilo B; Gerakis, Yannis; Hung, Mei-Li Diaz; Vidal, René; Fuentealba, Matias; Miedema, Tim; Duran-Aniotz, Claudia; Diaz, Javier; Ibaceta-Gonzalez, Cristobal; Sabusap, Carleen M; Bermedo-Garcia, Francisca; Mujica, Paula; Adamson, Stuart; Vitangcol, Kaitlyn; Huerta, Hernan; Zhang, Xu; Nakamura, Tomohiro; Sardi, Sergio Pablo; Lipton, Stuart A; Kennedy, Brian K; Henriquez, Juan Pablo; Cárdenas, J Cesar; Plate, Lars; Palacios, Adrian G; Hetz, Claudio.

EMBO J ; 41(22): e111952, 2022 11 17.

Article in English | MEDLINE | ID: mdl-36314651

6.

Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.

Oh, Chang-Ki; Nakamura, Tomohiro; Beutler, Nathan; Zhang, Xu; Piña-Crespo, Juan; Talantova, Maria; Ghatak, Swagata; Trudler, Dorit; Carnevale, Lauren N; McKercher, Scott R; Bakowski, Malina A; Diedrich, Jolene K; Roberts, Amanda J; Woods, Ashley K; Chi, Victor; Gupta, Anil K; Rosenfeld, Mia A; Kearns, Fiona L; Casalino, Lorenzo; Shaabani, Namir; Liu, Hejun; Wilson, Ian A; Amaro, Rommie E; Burton, Dennis R; Yates, John R; Becker, Cyrus; Rogers, Thomas F; Chatterjee, Arnab K; Lipton, Stuart A.

Nat Chem Biol ; 19(3): 275-283, 2023 03.

Article in English | MEDLINE | ID: mdl-36175661

7.

Novel Therapeutic Approach for Excitatory/Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases.

Ghatak, Swagata; Talantova, Maria; McKercher, Scott R; Lipton, Stuart A.

Annu Rev Pharmacol Toxicol ; 61: 701-721, 2021 01 06.

Article in English | MEDLINE | ID: mdl-32997602

8.

Stephen F. Heinemann: 1939-2014.

Lipton, Stuart A; Stevens, Charles F.

Cell ; 159(2): 231-2, 2014 Oct 09.

Article in English | MEDLINE | ID: mdl-25436266

9.

S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.

Pirie, Elaine; Oh, Chang-Ki; Zhang, Xu; Han, Xuemei; Cieplak, Piotr; Scott, Henry R; Deal, Amanda K; Ghatak, Swagata; Martinez, Fernando J; Yeo, Gene W; Yates, John R; Nakamura, Tomohiro; Lipton, Stuart A.

Proc Natl Acad Sci U S A ; 118(11)2021 03 16.

Article in English | MEDLINE | ID: mdl-33692125

10.

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.

Trudler, Dorit; Nazor, Kristopher L; Eisele, Yvonne S; Grabauskas, Titas; Dolatabadi, Nima; Parker, James; Sultan, Abdullah; Zhong, Zhenyu; Goodwin, Marshall S; Levites, Yona; Golde, Todd E; Kelly, Jeffery W; Sierks, Michael R; Schork, Nicholas J; Karin, Michael; Ambasudhan, Rajesh; Lipton, Stuart A.

Proc Natl Acad Sci U S A ; 118(15)2021 04 13.

Article in English | MEDLINE | ID: mdl-33833060

11.

S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.

Oh, Chang-Ki; Dolatabadi, Nima; Cieplak, Piotr; Diaz-Meco, Maria T; Moscat, Jorge; Nolan, John P; Nakamura, Tomohiro; Lipton, Stuart A.

J Neurosci ; 42(14): 3011-3024, 2022 04 06.

Article in English | MEDLINE | ID: mdl-35169022

12.

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.

Trudler, Dorit; Sanz-Blasco, Sara; Eisele, Yvonne S; Ghatak, Swagata; Bodhinathan, Karthik; Akhtar, Mohd Waseem; Lynch, William P; Piña-Crespo, Juan C; Talantova, Maria; Kelly, Jeffery W; Lipton, Stuart A.

J Neurosci ; 41(10): 2264-2273, 2021 03 10.

Article in English | MEDLINE | ID: mdl-33483428

13.

NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models.

Ghatak, Swagata; Dolatabadi, Nima; Gao, Richard; Wu, Yin; Scott, Henry; Trudler, Dorit; Sultan, Abdullah; Ambasudhan, Rajesh; Nakamura, Tomohiro; Masliah, Eliezer; Talantova, Maria; Voytek, Bradley; Lipton, Stuart A.

Mol Psychiatry ; 26(10): 5751-5765, 2021 10.

Article in English | MEDLINE | ID: mdl-32467645

14.

TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use.

Doulias, Paschalis-Thomas; Nakamura, Tomohiro; Scott, Henry; McKercher, Scott R; Sultan, Abdullah; Deal, Amanda; Albertolle, Matthew; Ischiropoulos, Harry; Lipton, Stuart A.

J Neurovirol ; 27(3): 367-378, 2021 06.

Article in English | MEDLINE | ID: mdl-33876414

15.

Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases.

Trudler, Dorit; Ghatak, Swagata; Lipton, Stuart A.

Int J Mol Sci ; 22(15)2021 Jul 30.

Article in English | MEDLINE | ID: mdl-34360966

16.

Reply to: Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.

Oh, Chang-Ki; Piña-Crespo, Juan; Talantova, Maria; Carnevale, Lauren N; Stoneham, Charlotte; Lewinski, Mary; Guatelli, John; Lipton, Stuart A.

Nat Chem Biol ; 19(11): 1306-1308, 2023 Nov.

Article in English | MEDLINE | ID: mdl-37798355

17.

MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.

Nagar, Saumya; Noveral, Sarah M; Trudler, Dorit; Lopez, Kevin M; McKercher, Scott R; Han, Xuemei; Yates, John R; Piña-Crespo, Juan C; Nakanishi, Nobuki; Satoh, Takumi; Okamoto, Shu-Ichi; Lipton, Stuart A.

Proc Natl Acad Sci U S A ; 114(20): E4048-E4056, 2017 05 16.

Article in English | MEDLINE | ID: mdl-28461502

18.

NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model.

Okamoto, Shu-Ichi; Prikhodko, Olga; Pina-Crespo, Juan; Adame, Anthony; McKercher, Scott R; Brill, Laurence M; Nakanishi, Nobuki; Oh, Chang-Ki; Nakamura, Tomohiro; Masliah, Eliezer; Lipton, Stuart A.

Neurobiol Dis ; 127: 390-397, 2019 07.

Article in English | MEDLINE | ID: mdl-30928642

19.

Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons.

Sunico, Carmen R; Sultan, Abdullah; Nakamura, Tomohiro; Dolatabadi, Nima; Parker, James; Shan, Bing; Han, Xuemei; Yates, John R; Masliah, Eliezer; Ambasudhan, Rajesh; Nakanishi, Nobuki; Lipton, Stuart A.

Proc Natl Acad Sci U S A ; 113(47): E7564-E7571, 2016 11 22.

Article in English | MEDLINE | ID: mdl-27821734

20.

Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.

Nakamura, Tomohiro; Wang, Lei; Wong, Catherine C L; Scott, Fiona L; Eckelman, Brendan P; Han, Xuemei; Tzitzilonis, Christos; Meng, Fanjun; Gu, Zezong; Holland, Emily A; Clemente, Arjay T; Okamoto, Shu-ichi; Salvesen, Guy S; Riek, Roland; Yates, John R; Lipton, Stuart A.

Mol Cell ; 39(2): 184-95, 2010 Jul 30.

Article in English | MEDLINE | ID: mdl-20670888

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