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1.

AKT/PKB Signaling: Navigating the Network.

Manning, Brendan D; Toker, Alex.

Cell ; 169(3): 381-405, 2017 04 20.

Article in English | MEDLINE | ID: mdl-28431241

2.

PI3K drives the de novo synthesis of coenzyme A from vitamin B5.

Dibble, Christian C; Barritt, Samuel A; Perry, Grace E; Lien, Evan C; Geck, Renee C; DuBois-Coyne, Sarah E; Bartee, David; Zengeya, Thomas T; Cohen, Emily B; Yuan, Min; Hopkins, Benjamin D; Meier, Jordan L; Clohessy, John G; Asara, John M; Cantley, Lewis C; Toker, Alex.

Nature ; 608(7921): 192-198, 2022 08.

Article in English | MEDLINE | ID: mdl-35896750

3.

Acetylation-dependent regulation of Skp2 function.

Inuzuka, Hiroyuki; Gao, Daming; Finley, Lydia W S; Yang, Wen; Wan, Lixin; Fukushima, Hidefumi; Chin, Y Rebecca; Zhai, Bo; Shaik, Shavali; Lau, Alan W; Wang, Zhiwei; Gygi, Steven P; Nakayama, Keiko; Teruya-Feldstein, Julie; Toker, Alex; Haigis, Marcia C; Pandolfi, Pier Paolo; Wei, Wenyi.

Cell ; 150(1): 179-93, 2012 Jul 06.

Article in English | MEDLINE | ID: mdl-22770219

4.

PI 3-Kinase Signaling: AKTing up inside the Cell.

Toker, Alex; Dibble, Christian C.

Mol Cell ; 71(6): 875-876, 2018 09 20.

Article in English | MEDLINE | ID: mdl-30241602

5.

PI3K signaling through a biochemical systems lens.

Madsen, Ralitsa R; Toker, Alex.

J Biol Chem ; 299(10): 105224, 2023 Oct.

Article in English | MEDLINE | ID: mdl-37673340

6.

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

Zhang, Jinfang; Xu, Kai; Liu, Pengda; Geng, Yan; Wang, Bin; Gan, Wenjian; Guo, Jianping; Wu, Fei; Chin, Y Rebecca; Berrios, Christian; Lien, Evan C; Toker, Alex; DeCaprio, James A; Sicinski, Piotr; Wei, Wenyi.

Mol Cell ; 62(6): 929-942, 2016 06 16.

Article in English | MEDLINE | ID: mdl-27237051

7.

Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.

Madsen, Ralitsa R; Erickson, Emily C; Rueda, Oscar M; Robin, Xavier; Caldas, Carlos; Toker, Alex; Semple, Robert K; Vanhaesebroeck, Bart.

PLoS Genet ; 17(11): e1009876, 2021 11.

Article in English | MEDLINE | ID: mdl-34762647

8.

Akt-ing up on SRPK1: oncogene or tumor suppressor?

Toker, Alex; Chin, Y Rebecca.

Mol Cell ; 54(3): 329-30, 2014 May 08.

Article in English | MEDLINE | ID: mdl-24813709

9.

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.

Gasser, Jessica A; Inuzuka, Hiroyuki; Lau, Alan W; Wei, Wenyi; Beroukhim, Rameen; Toker, Alex.

Mol Cell ; 56(4): 595-607, 2014 Nov 20.

Article in English | MEDLINE | ID: mdl-25458846

10.

Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy.

Geck, Renee C; Foley, Jackson R; Murray Stewart, Tracy; Asara, John M; Casero, Robert A; Toker, Alex.

J Biol Chem ; 295(19): 6263-6277, 2020 05 08.

Article in English | MEDLINE | ID: mdl-32139506

11.

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Liu, Pengda; Begley, Michael; Michowski, Wojciech; Inuzuka, Hiroyuki; Ginzberg, Miriam; Gao, Daming; Tsou, Peiling; Gan, Wenjian; Papa, Antonella; Kim, Byeong Mo; Wan, Lixin; Singh, Amrik; Zhai, Bo; Yuan, Min; Wang, Zhiwei; Gygi, Steven P; Lee, Tae Ho; Lu, Kun-Ping; Toker, Alex; Pandolfi, Pier Paolo; Asara, John M; Kirschner, Marc W; Sicinski, Piotr; Cantley, Lewis; Wei, Wenyi.

Nature ; 508(7497): 541-5, 2014 Apr 24.

Article in English | MEDLINE | ID: mdl-24670654

12.

Generative artificial intelligence in Journal of Biological Chemistry.

Colbran, Roger J; Toker, Alex.

J Biol Chem ; 299(8): 105008, 2023 08.

Article in English | MEDLINE | ID: mdl-37480742

13.

mTOR drives its own activation via SCF(ßTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

Gao, Daming; Inuzuka, Hiroyuki; Tan, Meng-Kwang Marcus; Fukushima, Hidefumi; Locasale, Jason W; Liu, Pengda; Wan, Lixin; Zhai, Bo; Chin, Y Rebecca; Shaik, Shavali; Lyssiotis, Costas A; Gygi, Steven P; Toker, Alex; Cantley, Lewis C; Asara, John M; Harper, J Wade; Wei, Wenyi.

Mol Cell ; 44(2): 290-303, 2011 Oct 21.

Article in English | MEDLINE | ID: mdl-22017875

14.

Can open science follow open access?

Toker, Alex.

J Biol Chem ; 298(1): 101473, 2022 01.

Article in English | MEDLINE | ID: mdl-34923237

15.

Sequence analysis of mutations and translocations across breast cancer subtypes.

Banerji, Shantanu; Cibulskis, Kristian; Rangel-Escareno, Claudia; Brown, Kristin K; Carter, Scott L; Frederick, Abbie M; Lawrence, Michael S; Sivachenko, Andrey Y; Sougnez, Carrie; Zou, Lihua; Cortes, Maria L; Fernandez-Lopez, Juan C; Peng, Shouyong; Ardlie, Kristin G; Auclair, Daniel; Bautista-Piña, Veronica; Duke, Fujiko; Francis, Joshua; Jung, Joonil; Maffuz-Aziz, Antonio; Onofrio, Robert C; Parkin, Melissa; Pho, Nam H; Quintanar-Jurado, Valeria; Ramos, Alex H; Rebollar-Vega, Rosa; Rodriguez-Cuevas, Sergio; Romero-Cordoba, Sandra L; Schumacher, Steven E; Stransky, Nicolas; Thompson, Kristin M; Uribe-Figueroa, Laura; Baselga, Jose; Beroukhim, Rameen; Polyak, Kornelia; Sgroi, Dennis C; Richardson, Andrea L; Jimenez-Sanchez, Gerardo; Lander, Eric S; Gabriel, Stacey B; Garraway, Levi A; Golub, Todd R; Melendez-Zajgla, Jorge; Toker, Alex; Getz, Gad; Hidalgo-Miranda, Alfredo; Meyerson, Matthew.

Nature ; 486(7403): 405-9, 2012 Jun 20.

Article in English | MEDLINE | ID: mdl-22722202

16.

The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.

Chin, Y Rebecca; Toker, Alex.

Mol Cell ; 38(3): 333-44, 2010 May 14.

Article in English | MEDLINE | ID: mdl-20471940

17.

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

Gao, Daming; Wan, Lixin; Inuzuka, Hiroyuki; Berg, Anders H; Tseng, Alan; Zhai, Bo; Shaik, Shavali; Bennett, Eric; Tron, Adriana E; Gasser, Jessica A; Lau, Alan; Gygi, Steven P; Harper, J Wade; DeCaprio, James A; Toker, Alex; Wei, Wenyi.

Mol Cell ; 39(5): 797-808, 2010 Sep 10.

Article in English | MEDLINE | ID: mdl-20832730

18.

mTOR and Akt signaling in cancer: SGK cycles in.

Toker, Alex.

Mol Cell ; 31(1): 6-8, 2008 Jul 11.

Article in English | MEDLINE | ID: mdl-18614042

19.

Signalling specificity in the Akt pathway in breast cancer.

Clark, Abbe R; Toker, Alex.

Biochem Soc Trans ; 42(5): 1349-55, 2014 Oct.

Article in English | MEDLINE | ID: mdl-25233414

20.

Minimizing Shear Stress in Cell Signaling Studies.

Mendez, Josefina; Toker, Alex.

Curr Protoc ; 4(3): e1019, 2024 Mar.

Article in English | MEDLINE | ID: mdl-38506433

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