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1.

Effective drug combinations in breast, colon and pancreatic cancer cells.

Jaaks, Patricia; Coker, Elizabeth A; Vis, Daniel J; Edwards, Olivia; Carpenter, Emma F; Leto, Simonetta M; Dwane, Lisa; Sassi, Francesco; Lightfoot, Howard; Barthorpe, Syd; van der Meer, Dieudonne; Yang, Wanjuan; Beck, Alexandra; Mironenko, Tatiana; Hall, Caitlin; Hall, James; Mali, Iman; Richardson, Laura; Tolley, Charlotte; Morris, James; Thomas, Frances; Lleshi, Ermira; Aben, Nanne; Benes, Cyril H; Bertotti, Andrea; Trusolino, Livio; Wessels, Lodewyk; Garnett, Mathew J.

Nature ; 603(7899): 166-173, 2022 03.

Article in English | MEDLINE | ID: mdl-35197630

2.

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Behan, Fiona M; Iorio, Francesco; Picco, Gabriele; Gonçalves, Emanuel; Beaver, Charlotte M; Migliardi, Giorgia; Santos, Rita; Rao, Yanhua; Sassi, Francesco; Pinnelli, Marika; Ansari, Rizwan; Harper, Sarah; Jackson, David Adam; McRae, Rebecca; Pooley, Rachel; Wilkinson, Piers; van der Meer, Dieudonne; Dow, David; Buser-Doepner, Carolyn; Bertotti, Andrea; Trusolino, Livio; Stronach, Euan A; Saez-Rodriguez, Julio; Yusa, Kosuke; Garnett, Mathew J.

Nature ; 568(7753): 511-516, 2019 04.

Article in English | MEDLINE | ID: mdl-30971826

3.

CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system.

Pernice, Simone; Sirovich, Roberta; Grassi, Elena; Viviani, Marco; Ferri, Martina; Sassi, Francesco; Alessandrì, Luca; Tortarolo, Dora; Calogero, Raffaele A; Trusolino, Livio; Bertotti, Andrea; Beccuti, Marco; Olivero, Martina; Cordero, Francesca.

Bioinformatics ; 39(5)2023 05 04.

Article in English | MEDLINE | ID: mdl-37079732

4.

MET signalling: principles and functions in development, organ regeneration and cancer.

Trusolino, Livio; Bertotti, Andrea; Comoglio, Paolo M.

Nat Rev Mol Cell Biol ; 11(12): 834-48, 2010 Dec.

Article in English | MEDLINE | ID: mdl-21102609

5.

The genomic landscape of response to EGFR blockade in colorectal cancer.

Bertotti, Andrea; Papp, Eniko; Jones, Siân; Adleff, Vilmos; Anagnostou, Valsamo; Lupo, Barbara; Sausen, Mark; Phallen, Jillian; Hruban, Carolyn A; Tokheim, Collin; Niknafs, Noushin; Nesselbush, Monica; Lytle, Karli; Sassi, Francesco; Cottino, Francesca; Migliardi, Giorgia; Zanella, Eugenia R; Ribero, Dario; Russolillo, Nadia; Mellano, Alfredo; Muratore, Andrea; Paraluppi, Gianluca; Salizzoni, Mauro; Marsoni, Silvia; Kragh, Michael; Lantto, Johan; Cassingena, Andrea; Li, Qing Kay; Karchin, Rachel; Scharpf, Robert; Sartore-Bianchi, Andrea; Siena, Salvatore; Diaz, Luis A; Trusolino, Livio; Velculescu, Victor E.

Nature ; 526(7572): 263-7, 2015 Oct 08.

Article in English | MEDLINE | ID: mdl-26416732

6.

Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer.

Lindner, Andreas U; Carberry, Steven; Monsefi, Naser; Barat, Ana; Salvucci, Manuela; O'Byrne, Robert; Zanella, Eugenia R; Cremona, Mattia; Hennessy, Bryan T; Bertotti, Andrea; Trusolino, Livio; Prehn, Jochen H M.

Int J Cancer ; 147(10): 2891-2901, 2020 11 15.

Article in English | MEDLINE | ID: mdl-32700762

7.

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.

Beekhof, Robin; van Alphen, Carolien; Henneman, Alex A; Knol, Jaco C; Pham, Thang V; Rolfs, Frank; Labots, Mariette; Henneberry, Evan; Le Large, Tessa Ys; de Haas, Richard R; Piersma, Sander R; Vurchio, Valentina; Bertotti, Andrea; Trusolino, Livio; Verheul, Henk Mw; Jimenez, Connie R.

Mol Syst Biol ; 15(4): e8250, 2019 04 12.

Article in English | MEDLINE | ID: mdl-30979792

8.

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer.

Sartore-Bianchi, Andrea; Amatu, Alessio; Porcu, Luca; Ghezzi, Silvia; Lonardi, Sara; Leone, Francesco; Bergamo, Francesca; Fenocchio, Elisabetta; Martinelli, Erika; Borelli, Beatrice; Tosi, Federica; Racca, Patrizia; Valtorta, Emanuele; Bonoldi, Emanuela; Martino, Cosimo; Vaghi, Caterina; Marrapese, Giovanna; Ciardiello, Fortunato; Zagonel, Vittorina; Bardelli, Alberto; Trusolino, Livio; Torri, Valter; Marsoni, Silvia; Siena, Salvatore.

Oncologist ; 24(10): 1395-1402, 2019 10.

Article in English | MEDLINE | ID: mdl-30952821

9.

Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.

Lupo, Barbara; Vialard, Jorge; Sassi, Francesco; Angibaud, Patrick; Puliafito, Alberto; Pupo, Emanuela; Lanzetti, Letizia; Comoglio, Paolo M; Bertotti, Andrea; Trusolino, Livio.

BMC Biol ; 14: 5, 2016 Jan 19.

Article in English | MEDLINE | ID: mdl-26787475

10.

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial.

Sartore-Bianchi, Andrea; Trusolino, Livio; Martino, Cosimo; Bencardino, Katia; Lonardi, Sara; Bergamo, Francesca; Zagonel, Vittorina; Leone, Francesco; Depetris, Ilaria; Martinelli, Erika; Troiani, Teresa; Ciardiello, Fortunato; Racca, Patrizia; Bertotti, Andrea; Siravegna, Giulia; Torri, Valter; Amatu, Alessio; Ghezzi, Silvia; Marrapese, Giovanna; Palmeri, Laura; Valtorta, Emanuele; Cassingena, Andrea; Lauricella, Calogero; Vanzulli, Angelo; Regge, Daniele; Veronese, Silvio; Comoglio, Paolo M; Bardelli, Alberto; Marsoni, Silvia; Siena, Salvatore.

Lancet Oncol ; 17(6): 738-746, 2016 Jun.

Article in English | MEDLINE | ID: mdl-27108243

11.

Inhibition of poly(ADP-ribosyl)ation in cancer: old and new paradigms revisited.

Lupo, Barbara; Trusolino, Livio.

Biochim Biophys Acta ; 1846(1): 201-15, 2014 Aug.

Article in English | MEDLINE | ID: mdl-25026313

12.

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.

Beekhof, Robin; van Alphen, Carolien; Henneman, Alex A; Knol, Jaco C; Pham, Thang V; Rolfs, Frank; Labots, Mariette; Henneberry, Evan; Le Large, Tessa Ys; de Haas, Richard R; Piersma, Sander R; Vurchio, Valentina; Bertotti, Andrea; Trusolino, Livio; Verheul, Henk Mw; Jimenez, Connie R.

Mol Syst Biol ; 15(5): e8981, 2019 May 24.

Article in English | MEDLINE | ID: mdl-31126969

13.

The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells.

Gentile, Alessandra; Lazzari, Luca; Benvenuti, Silvia; Trusolino, Livio; Comoglio, Paolo Maria.

Int J Cancer ; 135(10): 2305-16, 2014 Nov 15.

Article in English | MEDLINE | ID: mdl-24706440

14.

MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients.

Rocci, Alberto; Gambella, Manuela; Aschero, Simona; Baldi, Ileana; Trusolino, Livio; Cavallo, Federica; Gay, Francesca; Larocca, Alessandra; Magarotto, Valeria; Omedè, Paola; Isaia, Gianluca; Bertotti, Andrea; Liberati, Anna M; Catalano, Lucio; De Rosa, Luca; Musto, Pellegrino; Vallone, Roberto; Falcone, Antonietta; Drandi, Daniela; Ladetto, Marco; Comoglio, Paolo M; Boccadoro, Mario; Palumbo, Antonio.

Br J Haematol ; 164(6): 841-50, 2014 Mar.

Article in English | MEDLINE | ID: mdl-24450886

15.

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models.

Peraldo-Neia, Caterina; Cavalloni, Giuliana; Soster, Marco; Gammaitoni, Loretta; Marchiò, Serena; Sassi, Francesco; Trusolino, Livio; Bertotti, Andrea; Medico, Enzo; Capussotti, Lorenzo; Aglietta, Massimo; Leone, Francesco.

BMC Cancer ; 14: 918, 2014 Dec 05.

Article in English | MEDLINE | ID: mdl-25479910

16.

Animal research: Temper Italy's strict lab-animal law.

Trusolino, Livio; Bertotti, Andrea.

Nature ; 501(7465): 33, 2013 Sep 05.

Article in English | MEDLINE | ID: mdl-24005407

17.

Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells.

Sogari, Alberto; Rovera, Emanuele; Grasso, Gaia; Mariella, Elisa; Reilly, Nicole Megan; Lamba, Simona; Mauri, Gianluca; Durinikova, Erika; Vitiello, Pietro Paolo; Lorenzato, Annalisa; Avolio, Marco; Piumatti, Eleonora; Bonoldi, Emanuela; Aquilano, Maria Costanza; Arena, Sabrina; Sartore-Bianchi, Andrea; Siena, Salvatore; Trusolino, Livio; Donalisio, Manuela; Russo, Mariangela; Di Nicolantonio, Federica; Lembo, David; Bardelli, Alberto.

Cell Rep Med ; 5(2): 101376, 2024 Feb 20.

Article in English | MEDLINE | ID: mdl-38228147

18.

Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.

Malla, Sudhir B; Byrne, Ryan M; Lafarge, Maxime W; Corry, Shania M; Fisher, Natalie C; Tsantoulis, Petros K; Mills, Megan L; Ridgway, Rachel A; Lannagan, Tamsin R M; Najumudeen, Arafath K; Gilroy, Kathryn L; Amirkhah, Raheleh; Maguire, Sarah L; Mulholland, Eoghan J; Belnoue-Davis, Hayley L; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L; Sakhnevych, Svetlana; McCooey, Aoife J; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B; Kerr, Emma M; Tejpar, Sabine; Maughan, Timothy S; Lawler, Mark; Campbell, Andrew D; Leedham, Simon J; Koelzer, Viktor H; Sansom, Owen J; Dunne, Philip D.

Nat Genet ; 56(3): 458-472, 2024 Mar.

Article in English | MEDLINE | ID: mdl-38351382

19.

RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer.

Singh, Harshabad; Sahgal, Pranshu; Kapner, Kevin; Corsello, Steven M; Gupta, Hersh; Gujrathi, Rahul; Li, Yvonne Y; Cherniack, Andrew D; El Alam, Raquelle; Kerfoot, Joseph; Andrews, Elizabeth; Lee, Annette; Nambiar, Chetan; Hannigan, Alison M; Remland, Joshua; Brais, Lauren; Leahy, Meghan E; Rubinson, Douglas A; Schlechter, Benjamin L; Meyerson, Matthew; Kuang, Yanan; Paweletz, Cloud P; Lee, Jessica K; Quintanilha, Julia C F; Aguirre, Andrew J; Perez, Kimberly J; Huffman, Brandon M; Rossi, Humberto; Abrams, Thomas A; Kabraji, Sheheryar; Trusolino, Livio; Bertotti, Andrea; Sicinska, Ewa T; Parikh, Aparna R; Wolpin, Brian M; Schrock, Alexa B; Giannakis, Marios; Ng, Kimmie; Meyerhardt, Jeffrey A; Hornick, Jason L; Sethi, Nilay S; Cleary, James M.

Clin Cancer Res ; 30(8): 1669-1684, 2024 Apr 15.

Article in English | MEDLINE | ID: mdl-38345769

20.

Scatter-factor and semaphorin receptors: cell signalling for invasive growth.

Trusolino, Livio; Comoglio, Paolo M.

Nat Rev Cancer ; 2(4): 289-300, 2002 Apr.

Article in English | MEDLINE | ID: mdl-12001990

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Effective drug combinations in breast, colon and pancreatic cancer cells.

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system.

MET signalling: principles and functions in development, organ regeneration and cancer.

The genomic landscape of response to EGFR blockade in colorectal cancer.

Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer.

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer.

Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial.

Inhibition of poly(ADP-ribosyl)ation in cancer: old and new paradigms revisited.

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.

The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells.

MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients.

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models.

Animal research: Temper Italy's strict lab-animal law.

Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells.

Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.

RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer.

Scatter-factor and semaphorin receptors: cell signalling for invasive growth.