Detalhe da pesquisa
1.
Low-molecular weight inhibitors of the alternative complement pathway.
Immunol Rev
; 313(1): 339-357, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36217774
2.
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc Natl Acad Sci U S A
; 116(16): 7926-7931, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926668
3.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat Chem Biol
; 12(12): 1105-1110, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27775713
4.
Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria.
Haematologica
; 107(6): 1483-1488, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35263983
5.
The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures.
J Neuroinflammation
; 13: 31, 2016 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26856814
6.
Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis.
J Neuroinflammation
; 13(1): 207, 2016 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27566665
7.
Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation.
Toxicol Pathol
; 43(5): 694-703, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25630683
8.
In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway.
Front Immunol
; 14: 1180833, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37457736
9.
Disease Association of AntiâCarboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa.
J Invest Dermatol
; 143(2): 273-283.e12, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36116506
10.
Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b.
Front Immunol
; 13: 1020580, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36578495
11.
Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals.
Front Immunol
; 12: 747594, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34691058
12.
Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights.
Mult Scler J Exp Transl Clin
; 7(4): 20552173211049168, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34777855
13.
Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals.
Front Immunol
; 12: 732146, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34707606
14.
Subcutaneous anti-CD20 antibody treatment delays gray matter atrophy in human myelin oligodendrocyte glycoprotein-induced EAE mice.
Exp Neurol
; 335: 113488, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32991933
15.
Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer.
Cancer Immunol Res
; 9(7): 790-810, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33990375
16.
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J Med Chem
; 63(11): 5697-5722, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32073845
17.
The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis.
Neural Regen Res
; 14(11): 1950-1960, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31290453
18.
Central nervous system-directed effects of FTY720 (fingolimod).
J Neurol Sci
; 274(1-2): 13-7, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678377
19.
Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice.
J Clin Invest
; 112(4): 544-53, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12925695
20.
Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat.
Brain
; 127(Pt 8): 1822-30, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15201193