Detalhe da pesquisa
1.
Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB.
J Pharmacol Exp Ther
; 382(3): 277-286, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35717448
2.
Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys.
Toxicol Rep
; 10: 357-366, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36923444
3.
Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat.
Drug Metab Dispos
; 40(8): 1515-26, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22577085
4.
Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes.
Drug Metab Dispos
; 38(1): 133-42, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19786506
5.
Central nervous system pathology in preclinical MPS IIIB dogs reveals progressive changes in clinically relevant brain regions.
Sci Rep
; 10(1): 20365, 2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33230178
6.
Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B.
Drug Deliv Transl Res
; 10(2): 425-439, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31942701
7.
Discovery of AMG 853, a CRTH2 and DP Dual Antagonist.
ACS Med Chem Lett
; 2(5): 326-30, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900313
8.
Metabolism of [14C]gemopatrilat after oral administration to rats, dogs, and humans.
Drug Metab Dispos
; 34(6): 961-70, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16540589