Detalhe da pesquisa
1.
Radiolabelling and preclinical characterization of 89Zr-Df-radiolabelled bispecific anti-PD-L1/TGF-ßRII fusion protein bintrafusp alfa.
Eur J Nucl Med Mol Imaging
; 48(10): 3075-3088, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33608805
2.
Simulations of site-specific target-mediated pharmacokinetic models for guiding the development of bispecific antibodies.
J Pharmacokinet Pharmacodyn
; 42(1): 1-18, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25559227
3.
A mechanistic pharmacodynamic model of IRAK-4 drug inhibition in the Toll-like receptor pathway.
J Pharmacokinet Pharmacodyn
; 40(5): 609-22, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24097307
4.
Mathematical modeling of SARS-CoV-2 viral dynamics and treatment with monoclonal antibodies.
IFAC Pap OnLine
; 55(23): 175-179, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-38620987
5.
Bispecific antibodies: A guide to model informed drug discovery and development.
Heliyon
; 7(7): e07649, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34381902
6.
Identifying Safety Thresholds for Immunosuppressive Drugs: Applying Insights from Primary Antibody Deficiencies to Mitigate Adverse Events in Secondary Antibody Deficiencies Using Mathematical Modeling of Preclinical and Early Clinical Data.
Eur J Drug Metab Pharmacokinet
; 46(5): 601-611, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34328632
7.
Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Clin Pharmacol Ther
; 109(3): 605-618, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32686076
8.
Saturation of multidrug-resistant protein 2 (mrp2/abcc2)-mediated hepatobiliary secretion: nonlinear pharmacokinetics of a heterocyclic compound in rats after intravenous bolus administration.
Drug Metab Dispos
; 37(4): 841-6, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19139164
9.
Guiding principles for mechanistic modeling of bispecific antibodies.
Prog Biophys Mol Biol
; 139: 59-72, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30201490
10.
Optimal Affinity of a Monoclonal Antibody: Guiding Principles Using Mechanistic Modeling.
AAPS J
; 19(2): 510-519, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28004347
11.
Correction to: Identifying Safety Thresholds for Immunosuppressive Drugs: Applying Insights from Primary Antibody Deficiencies to Mitigate Adverse Events in Secondary Antibody Deficiencies Using Mathematical Modeling of Preclinical and Early Clinical Data.
Eur J Drug Metab Pharmacokinet
; 46(6): 827, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34581976
12.
Quantitative prediction of human pharmacokinetics for mAbs exhibiting target-mediated disposition.
AAPS J
; 17(2): 389-99, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25445845
13.
Toxicokinetics of 2-methylimidazole in male and female F344 rats.
J Toxicol Environ Health A
; 65(12): 869-79, 2002 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-12079612
14.
Erratum to: Optimal Affinity of a Monoclonal Antibody: Guiding Principles Using Mechanistic Modeling.
AAPS J
; 19(2): 597, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28097628
15.
Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).
ACS Med Chem Lett
; 1(2): 59-63, 2010 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900177