Detalhe da pesquisa
1.
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
Cell
; 170(3): 457-469.e13, 2017 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28753425
2.
Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.
Mol Cell
; 77(3): 669-680.e4, 2020 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32004470
3.
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature
; 558(7711): 553-558, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29899450
4.
Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature
; 561(7724): E44, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29930353
5.
Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature
; 560(7720): 666-670, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30135577
6.
Molecular mechanisms of fentanyl mediated ß-arrestin biased signaling.
PLoS Comput Biol
; 16(4): e1007394, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32275713
7.
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.
Nature
; 523(7562): 561-7, 2015 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26200343
8.
Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).
J Biol Chem
; 293(44): 16994-17007, 2018 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30206123
9.
Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors.
J Biol Chem
; 292(24): 9865-9881, 2017 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28356352
10.
Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing.
J Biol Chem
; 292(30): 12653-12666, 2017 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28615457
11.
The structural basis of the dominant negative phenotype of the Gαi1ß1γ2 G203A/A326S heterotrimer.
Acta Pharmacol Sin
; 37(9): 1259-72, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27498775
12.
A fast, open source implementation of adaptive biasing potentials uncovers a ligand design strategy for the chromatin regulator BRD4.
J Chem Phys
; 145(15): 154113, 2016 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27782467
13.
Structural mechanism of a drug-binding process involving a large conformational change of the protein target.
Nat Commun
; 14(1): 1885, 2023 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37019905
14.
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.
Nat Commun
; 11(1): 885, 2020 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32060286
15.
Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
Structure
; 27(12): 1862-1874.e7, 2019 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31669042
16.
A complex structure of arrestin-2 bound to a G protein-coupled receptor.
Cell Res
; 29(12): 971-983, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31776446
17.
Structure and dynamics of the active human parathyroid hormone receptor-1.
Science
; 364(6436): 148-153, 2019 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30975883
18.
Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist.
Cell Discov
; 4: 12, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29560272
19.
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J Med Chem
; 59(17): 7856-76, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27458733
20.
X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.
Sci Data
; 3: 160021, 2016 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27070998