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1.
Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity.
J Biol Chem
; 296: 100349, 2021.
Article
in English
| MEDLINE | ID: mdl-33524394
2.
Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of HSV-1/2 and HIV from cells.
J Virol
; 95(11)2021 05 10.
Article
in English
| MEDLINE | ID: mdl-33731460
3.
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Bioorg Med Chem
; 28(1): 115194, 2020 01 01.
Article
in English
| MEDLINE | ID: mdl-31786008
4.
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
J Biol Chem
; 291(25): 13014-27, 2016 Jun 17.
Article
in English
| MEDLINE | ID: mdl-27056325
5.
The potent BACE1 inhibitor LY2886721 elicits robust central Aß pharmacodynamic responses in mice, dogs, and humans.
J Neurosci
; 35(3): 1199-210, 2015 Jan 21.
Article
in English
| MEDLINE | ID: mdl-25609634
6.
Identification of potent, selective KDM5 inhibitors.
Bioorg Med Chem Lett
; 26(17): 4350-4, 2016 09 01.
Article
in English
| MEDLINE | ID: mdl-27476424
7.
Discovery, design, and synthesis of indole-based EZH2 inhibitors.
Bioorg Med Chem Lett
; 25(17): 3644-9, 2015 Sep 01.
Article
in English
| MEDLINE | ID: mdl-26189078
8.
Development of methyl isoxazoleazepines as inhibitors of BET.
Bioorg Med Chem Lett
; 25(9): 1842-8, 2015 May 01.
Article
in English
| MEDLINE | ID: mdl-25851940
9.
Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Bioorg Med Chem
; 23(13): 3260-8, 2015 Jul 01.
Article
in English
| MEDLINE | ID: mdl-26001341
10.
Robust central reduction of amyloid-ß in humans with an orally available, non-peptidic ß-secretase inhibitor.
J Neurosci
; 31(46): 16507-16, 2011 Nov 16.
Article
in English
| MEDLINE | ID: mdl-22090477
11.
Corrigendum: The promise and peril of chemical probes.
Nat Chem Biol
; 11(11): 887, 2015 Nov.
Article
in English
| MEDLINE | ID: mdl-26485080
12.
The promise and peril of chemical probes.
Nat Chem Biol
; 11(8): 536-41, 2015 Aug.
Article
in English
| MEDLINE | ID: mdl-26196764
13.
Collaboration and knowledge integration for successful brain therapeutics - lessons learned from the pandemic.
Dis Model Mech
; 15(12)2022 12 01.
Article
in English
| MEDLINE | ID: mdl-36541917
14.
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J Med Chem
; 65(16): 11177-11186, 2022 08 25.
Article
in English
| MEDLINE | ID: mdl-35930799
15.
Mentoring Matters in Drug Discovery.
ACS Med Chem Lett
; 11(3): 241-244, 2020 Mar 12.
Article
in English
| MEDLINE | ID: mdl-32184951
16.
Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.
ChemMedChem
; 15(11): 955-960, 2020 06 04.
Article
in English
| MEDLINE | ID: mdl-32181984
17.
Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time.
ACS Med Chem Lett
; 11(6): 1205-1212, 2020 Jun 11.
Article
in English
| MEDLINE | ID: mdl-32551002
18.
Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors.
ACS Med Chem Lett
; 11(6): 1213-1220, 2020 Jun 11.
Article
in English
| MEDLINE | ID: mdl-32551003
19.
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.
J Med Chem
; 61(20): 9301-9315, 2018 10 25.
Article
in English
| MEDLINE | ID: mdl-30289257
20.
GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).
ACS Med Chem Lett
; 8(7): 737-741, 2017 Jul 13.
Article
in English
| MEDLINE | ID: mdl-28740608