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1.
TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31.
Hum Mol Genet
; 27(16): 2893-2912, 2018 08 15.
Article
in English
| MEDLINE | ID: mdl-29860333
2.
A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
Hum Mol Genet
; 25(22): 4920-4938, 2016 11 15.
Article
in English
| MEDLINE | ID: mdl-28171570
3.
A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.
J Neurosci
; 33(48): 18712-27, 2013 Nov 27.
Article
in English
| MEDLINE | ID: mdl-24285878
4.
Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington's Disease.
J Huntingtons Dis
; 12(3): 215-239, 2023.
Article
in English
| MEDLINE | ID: mdl-37638447
5.
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.
J Neurosci
; 29(18): 5938-48, 2009 May 06.
Article
in English
| MEDLINE | ID: mdl-19420260
6.
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation.
Neurobiol Dis
; 34(1): 71-7, 2009 Apr.
Article
in English
| MEDLINE | ID: mdl-19167498
7.
Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.
Acta Neuropathol Commun
; 6(1): 100, 2018 09 24.
Article
in English
| MEDLINE | ID: mdl-30249297
8.
[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease.
Theranostics
; 7(6): 1422-1436, 2017.
Article
in English
| MEDLINE | ID: mdl-28529627
9.
Microglial complement receptor 3 regulates brain Aß levels through secreted proteolytic activity.
J Exp Med
; 214(4): 1081-1092, 2017 04 03.
Article
in English
| MEDLINE | ID: mdl-28298456
10.
PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2,5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl)acetamide.
J Nucl Med
; 56(2): 311-6, 2015 Feb.
Article
in English
| MEDLINE | ID: mdl-25613536
11.
A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.
PLoS One
; 9(8): e102136, 2014.
Article
in English
| MEDLINE | ID: mdl-25153701
12.
Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AßPP(L/S) transgenic mice.
J Alzheimers Dis
; 42(2): 459-83, 2014.
Article
in English
| MEDLINE | ID: mdl-24898660
13.
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks.
J Comp Neurol
; 514(3): 240-58, 2009 May 20.
Article
in English
| MEDLINE | ID: mdl-19296534
14.
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome.
J Comp Neurol
; 508(1): 184-95, 2008 May 01.
Article
in English
| MEDLINE | ID: mdl-18306326
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