Search details
1.
Identification of New Compounds against PRRSV Infection by Directly Targeting CD163.
J Virol
; 97(5): e0005423, 2023 05 31.
Article
in English
| MEDLINE | ID: mdl-37133376
2.
Tetrapyrrolic Pigments from Heme- and Chlorophyll Breakdown are Actin-Targeting Compounds.
Angew Chem Int Ed Engl
; 60(41): 22578-22584, 2021 10 04.
Article
in English
| MEDLINE | ID: mdl-34310831
3.
Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells.
Virol J
; 17(1): 116, 2020 07 30.
Article
in English
| MEDLINE | ID: mdl-32727587
4.
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Angew Chem Int Ed Engl
; 57(6): 1601-1605, 2018 02 05.
Article
in English
| MEDLINE | ID: mdl-29284071
5.
Activating STAT6 mutations in follicular lymphoma.
Blood
; 125(4): 668-79, 2015 Jan 22.
Article
in English
| MEDLINE | ID: mdl-25428220
6.
High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J Am Chem Soc
; 135(2): 669-82, 2013 Jan 16.
Article
in English
| MEDLINE | ID: mdl-23210835
7.
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors.
J Am Chem Soc
; 135(19): 7223-34, 2013 May 15.
Article
in English
| MEDLINE | ID: mdl-23641733
8.
Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia.
iScience
; 25(4): 104170, 2022 Apr 15.
Article
in English
| MEDLINE | ID: mdl-35465359
9.
Split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions.
J Biol Chem
; 285(27): 21023-36, 2010 Jul 02.
Article
in English
| MEDLINE | ID: mdl-20413594
10.
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.
Proc Natl Acad Sci U S A
; 105(10): 3933-8, 2008 Mar 11.
Article
in English
| MEDLINE | ID: mdl-18316739
11.
Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation.
Clin Cancer Res
; 27(8): 2301-2313, 2021 04 15.
Article
in English
| MEDLINE | ID: mdl-33419778
12.
Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity.
Nat Commun
; 12(1): 2621, 2021 05 11.
Article
in English
| MEDLINE | ID: mdl-33976147
13.
Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
ACS Med Chem Lett
; 11(6): 1348-1352, 2020 Jun 11.
Article
in English
| MEDLINE | ID: mdl-32551023
14.
Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer.
Mol Cancer Ther
; 7(6): 1533-42, 2008 Jun.
Article
in English
| MEDLINE | ID: mdl-18566224
15.
Follicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR.
J Clin Invest
; 129(4): 1626-1640, 2019 03 04.
Article
in English
| MEDLINE | ID: mdl-30720463
16.
Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.
J Med Chem
; 62(13): 6015-6034, 2019 07 11.
Article
in English
| MEDLINE | ID: mdl-31244110
17.
High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.
J Med Chem
; 61(5): 1934-1950, 2018 03 08.
Article
in English
| MEDLINE | ID: mdl-29438612
18.
Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.
J Med Chem
; 50(8): 1799-809, 2007 Apr 19.
Article
in English
| MEDLINE | ID: mdl-17367120
19.
Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges.
Cold Spring Harb Perspect Med
; 7(5)2017 May 01.
Article
in English
| MEDLINE | ID: mdl-28270530
20.
A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation.
Nat Commun
; 8(1): 1150, 2017 10 27.
Article
in English
| MEDLINE | ID: mdl-29074978