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1.
Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.
Bioorg Med Chem
; 71: 116942, 2022 10 01.
Article
in English
| MEDLINE | ID: mdl-35930851
2.
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Angew Chem Int Ed Engl
; 57(6): 1601-1605, 2018 02 05.
Article
in English
| MEDLINE | ID: mdl-29284071
3.
CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge.
J Chem Inf Model
; 56(6): 1022-31, 2016 06 27.
Article
in English
| MEDLINE | ID: mdl-26419257
4.
CSAR data set release 2012: ligands, affinities, complexes, and docking decoys.
J Chem Inf Model
; 53(8): 1842-52, 2013 Aug 26.
Article
in English
| MEDLINE | ID: mdl-23617227
5.
Correction to "Profiling the Binding Activities of Peptides and Inhibitors to the U2 Auxiliary Factor Homology Motif (UHM) Domains".
ACS Med Chem Lett
; 14(5): 681, 2023 May 11.
Article
in English
| MEDLINE | ID: mdl-37197465
6.
Profiling the Binding Activities of Peptides and Inhibitors to the U2 Auxiliary Factor Homology Motif (UHM) Domains.
ACS Med Chem Lett
; 14(4): 450-457, 2023 Apr 13.
Article
in English
| MEDLINE | ID: mdl-37077390
7.
Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors.
ACS Pharmacol Transl Sci
; 6(9): 1275-1287, 2023 Sep 08.
Article
in English
| MEDLINE | ID: mdl-37705593
8.
Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding.
J Phys Chem B
; 126(12): 2394-2406, 2022 03 31.
Article
in English
| MEDLINE | ID: mdl-35294837
9.
Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity.
Nat Commun
; 12(1): 2621, 2021 05 11.
Article
in English
| MEDLINE | ID: mdl-33976147
10.
SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
ACS Med Chem Lett
; 12(6): 996-1004, 2021 Jun 10.
Article
in English
| MEDLINE | ID: mdl-34141084
11.
Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
J Med Chem
; 64(14): 10333-10349, 2021 07 22.
Article
in English
| MEDLINE | ID: mdl-34196551
12.
Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
J Med Chem
; 64(19): 14540-14556, 2021 10 14.
Article
in English
| MEDLINE | ID: mdl-34613724
13.
Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.
J Med Chem
; 63(9): 4997-5010, 2020 05 14.
Article
in English
| MEDLINE | ID: mdl-32338903
14.
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
J Med Chem
; 63(5): 2489-2510, 2020 03 12.
Article
in English
| MEDLINE | ID: mdl-31971799
15.
EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.
J Med Chem
; 63(13): 7252-7267, 2020 07 09.
Article
in English
| MEDLINE | ID: mdl-32580550
16.
Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER).
J Med Chem
; 62(3): 1420-1442, 2019 02 14.
Article
in English
| MEDLINE | ID: mdl-30990042
17.
Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.
J Med Chem
; 62(24): 11218-11231, 2019 12 26.
Article
in English
| MEDLINE | ID: mdl-31804827
18.
Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer.
J Med Chem
; 62(2): 941-964, 2019 01 24.
Article
in English
| MEDLINE | ID: mdl-30629437
19.
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Cancer Cell
; 36(5): 498-511.e17, 2019 11 11.
Article
in English
| MEDLINE | ID: mdl-31715132
20.
Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.
J Med Chem
; 62(13): 6015-6034, 2019 07 11.
Article
in English
| MEDLINE | ID: mdl-31244110