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1.
Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020.
Antimicrob Agents Chemother
; 66(5): e0005422, 2022 05 17.
Article
in English
| MEDLINE | ID: mdl-35471042
2.
Small-molecule sensitization of RecBCD helicase-nuclease to a Chi hotspot-activated state.
Nucleic Acids Res
; 48(14): 7973-7980, 2020 08 20.
Article
in English
| MEDLINE | ID: mdl-32597964
3.
Unraveling the Gentamicin Drug Product Complexity Reveals Variation in Microbiological Activities and Nephrotoxicity.
Antimicrob Agents Chemother
; 64(9)2020 08 20.
Article
in English
| MEDLINE | ID: mdl-32601158
4.
Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa.
Antimicrob Agents Chemother
; 63(11)2019 11.
Article
in English
| MEDLINE | ID: mdl-31451507
5.
Natural History of Francisella tularensis in Aerosol-Challenged BALB/c Mice.
Antimicrob Agents Chemother
; 60(3): 1834-40, 2016 Jan 11.
Article
in English
| MEDLINE | ID: mdl-26824958
6.
Plazomicin is effective in a non-human primate pneumonic plague model.
Bioorg Med Chem
; 24(24): 6429-6439, 2016 12 15.
Article
in English
| MEDLINE | ID: mdl-27614915
7.
Interaction of drug- and granulocyte-mediated killing of Pseudomonas aeruginosa in a murine pneumonia model.
J Infect Dis
; 210(8): 1319-24, 2014 Oct 15.
Article
in English
| MEDLINE | ID: mdl-24760199
8.
Natural history of Yersinia pestis pneumonia in aerosol-challenged BALB/c mice.
Antimicrob Agents Chemother
; 57(5): 2010-5, 2013 May.
Article
in English
| MEDLINE | ID: mdl-23403418
9.
Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
J Med Chem
; 62(16): 7489-7505, 2019 08 22.
Article
in English
| MEDLINE | ID: mdl-31306011
10.
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
ChemMedChem
; 14(16): 1560-1572, 2019 08 20.
Article
in English
| MEDLINE | ID: mdl-31283109
11.
Inhibition of mutation and combating the evolution of antibiotic resistance.
PLoS Biol
; 3(6): e176, 2005 Jun.
Article
in English
| MEDLINE | ID: mdl-15869329
12.
Side effects may include evolution.
Nat Med
; 12(8): 890-1, 2006 Aug.
Article
in English
| MEDLINE | ID: mdl-16892033
13.
Structural and initial biological analysis of synthetic arylomycin A2.
J Am Chem Soc
; 129(51): 15830-8, 2007 Dec 26.
Article
in English
| MEDLINE | ID: mdl-18052061
14.
Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones.
ChemMedChem
; 12(20): 1687-1692, 2017 10 20.
Article
in English
| MEDLINE | ID: mdl-28881459
15.
Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones.
Open Biol
; 6(9)2016 Sep.
Article
in English
| MEDLINE | ID: mdl-27655731
16.
Controlling mutation: intervening in evolution as a therapeutic strategy.
Crit Rev Biochem Mol Biol
; 42(5): 341-54, 2007.
Article
in English
| MEDLINE | ID: mdl-17917871
17.
Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin.
J Bacteriol
; 189(2): 531-9, 2007 Jan.
Article
in English
| MEDLINE | ID: mdl-17085555
18.
Induction and inhibition of ciprofloxacin resistance-conferring mutations in hypermutator bacteria.
Antimicrob Agents Chemother
; 50(1): 220-5, 2006 Jan.
Article
in English
| MEDLINE | ID: mdl-16377689
19.
Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin.
J Bacteriol
; 188(20): 7101-10, 2006 Oct.
Article
in English
| MEDLINE | ID: mdl-17015649
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