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1.
Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist.
Mol Pharmacol
; 79(1): 69-76, 2011 Jan.
Article
in English
| MEDLINE | ID: mdl-20943773
2.
The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid.
Bioorg Med Chem Lett
; 21(2): 734-7, 2011 Jan 15.
Article
in English
| MEDLINE | ID: mdl-21208803
3.
A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.
Bioorg Med Chem Lett
; 21(1): 484-7, 2011 Jan 01.
Article
in English
| MEDLINE | ID: mdl-21126875
4.
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Bioorg Med Chem Lett
; 21(3): 1041-6, 2011 Feb 01.
Article
in English
| MEDLINE | ID: mdl-21215624
5.
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Bioorg Med Chem Lett
; 21(1): 288-93, 2011 Jan 01.
Article
in English
| MEDLINE | ID: mdl-21106375
6.
Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore.
Bioorg Med Chem Lett
; 20(24): 7462-5, 2010 Dec 15.
Article
in English
| MEDLINE | ID: mdl-21036609
7.
Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
Bioorg Med Chem Lett
; 20(12): 3760-3, 2010 Jun 15.
Article
in English
| MEDLINE | ID: mdl-20471829
8.
Discovery of potent and selective DP1 receptor antagonists in the azaindole series.
Bioorg Med Chem Lett
; 19(8): 2125-8, 2009 Apr 15.
Article
in English
| MEDLINE | ID: mdl-19307115
9.
MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
J Pharmacol Exp Ther
; 325(2): 425-34, 2008 May.
Article
in English
| MEDLINE | ID: mdl-18287210
10.
Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.
Bioorg Med Chem Lett
; 18(8): 2696-700, 2008 Apr 15.
Article
in English
| MEDLINE | ID: mdl-18359630
11.
Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.
Bioorg Med Chem Lett
; 18(6): 2048-54, 2008 Mar 15.
Article
in English
| MEDLINE | ID: mdl-18291643
12.
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
J Med Chem
; 50(4): 794-806, 2007 Feb 22.
Article
in English
| MEDLINE | ID: mdl-17300164
13.
The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
J Med Chem
; 53(5): 2227-38, 2010 Mar 11.
Article
in English
| MEDLINE | ID: mdl-20163116
14.
Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis.
Eur J Immunol
; 38(7): 1900-12, 2008 Jul.
Article
in English
| MEDLINE | ID: mdl-18506884
15.
Comparison between two classes of selective EP(3) antagonists and their biological activities.
Bioorg Med Chem Lett
; 16(21): 5639-42, 2006 Nov 01.
Article
in English
| MEDLINE | ID: mdl-16931013
16.
Identification of an indole series of prostaglandin D2 receptor antagonists.
Bioorg Med Chem Lett
; 16(11): 3043-8, 2006 Jun 01.
Article
in English
| MEDLINE | ID: mdl-16529930
17.
Identification of a potent and selective synthetic agonist at the CRTH2 receptor.
Mol Pharmacol
; 67(6): 1834-9, 2005 Jun.
Article
in English
| MEDLINE | ID: mdl-15755909
18.
2,3-Diarylthiophenes as selective EP1 receptor antagonists.
Bioorg Med Chem Lett
; 15(4): 1155-60, 2005 Feb 15.
Article
in English
| MEDLINE | ID: mdl-15686932
19.
Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists.
Bioorg Med Chem Lett
; 15(3): 527-30, 2005 Feb 01.
Article
in English
| MEDLINE | ID: mdl-15664806
20.
Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis.
Bioorg Med Chem Lett
; 14(12): 3195-9, 2004 Jun 21.
Article
in English
| MEDLINE | ID: mdl-15149674